Status
Please wait ...

Details for anatomical structure: preadipocyte

EndoNet ID: ENC00542

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

preadipocyte, ,

General information

Preadipocytes are present throughout adult life in adipose tissues and can proliferate and differentiate into mature adipocytes

Links to other resources

Cytomer cy0044758

Larger structures

    Substructures

      Secreted hormones

      • Hormone: VEGF-165

        Influenced by:

        • leptin receptor
          in preadipocyte
          • Leptin induced VEGF mRNA expression in cultured pre-adipocytes but not in adipocytes. [1]

      Receptors

      • Receptor: leptin receptor

        Influences:

        • VEGF-165
          • Leptin induced VEGF mRNA expression in cultured pre-adipocytes but not in adipocytes. [1]
      • Receptor: PRLR

        Induced phenotype:

        • differentiation of preadipocytes
          • Prolactin induces differentiation of preadipocytes. Prolactin and its receptor play a role in differentiation and/or metabolism of pre-adipocytes and adipocytes. [2]
      • Receptor: Lysophosphatidic acid receptor 1

        Induced phenotype:

        • negative regulation of fat cell differentiation
          • LPA1 signaling appears to be antiadipogenic because stimulation of LPA1 signaling inhibits the differentiation of preadipocytes. This inhibitory effect is the result of the downregulation of PPAR╬│2. [3]
        • positive regulation of cell motility
          • The first indications that LPA is involved in adipogenesis were based on the observations that LPA is released by adipocytes, but not by preadipocytes, in vivo and in vitro, and LPA stimulates motility of preadipocytes through LPA1. [4]
        • positive regulation of fat cell proliferation
          • The first indications that LPA is involved in adipogenesis were based on the observations that LPA is released by adipocytes, but not by preadipocytes, in vivo and in vitro, and LPA stimulates proliferation of preadipocytes through LPA1. [5]
        • positive regulation of glucose import
          • It is indicated that LPA signaling, possibly through LPA1, regulates blood glucose levels by enhancing glucose uptake by adipocytes and thereby resulting in an LPA-induced glucose-lowering effect. [6]
      Reference