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Details for anatomical structure: preadipocyte

EndoNet ID: ENC00542

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Synonyms

preadipocyte, ,

General information

Preadipocytes are present throughout adult life in adipose tissues and can proliferate and differentiate into mature adipocytes

Links to other resources

Cytomer cy0044758

Larger structures

    Substructures

      Secreted hormones

      • Hormone: VEGF-165

        Influenced by:

        • leptin receptor
          in preadipocyte
          • Leptin induced VEGF mRNA expression in cultured pre-adipocytes but not in adipocytes. [1]

      Receptors

      • Receptor: leptin receptor

        Influences:

        • VEGF-165
          • Leptin induced VEGF mRNA expression in cultured pre-adipocytes but not in adipocytes. [1]

      • Receptor: PRLR

        Induced phenotype:

        • differentiation of preadipocytes
          • Prolactin induces differentiation of preadipocytes. Prolactin and its receptor play a role in differentiation and/or metabolism of pre-adipocytes and adipocytes. [2]

      • Receptor: Lysophosphatidic acid receptor 1

        Induced phenotype:

        • negative regulation of fat cell differentiation
          • LPA1 signaling appears to be antiadipogenic because stimulation of LPA1 signaling inhibits the differentiation of preadipocytes. This inhibitory effect is the result of the downregulation of PPARγ2. [3]
        • positive regulation of cell motility
          • The first indications that LPA is involved in adipogenesis were based on the observations that LPA is released by adipocytes, but not by preadipocytes, in vivo and in vitro, and LPA stimulates motility of preadipocytes through LPA1. [4]
        • positive regulation of fat cell proliferation
          • The first indications that LPA is involved in adipogenesis were based on the observations that LPA is released by adipocytes, but not by preadipocytes, in vivo and in vitro, and LPA stimulates proliferation of preadipocytes through LPA1. [5]
        • positive regulation of glucose import
          • It is indicated that LPA signaling, possibly through LPA1, regulates blood glucose levels by enhancing glucose uptake by adipocytes and thereby resulting in an LPA-induced glucose-lowering effect. [6]
      Reference