Details for anatomical structure: preadipocyte
- Top
- General information
- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
- Top
- General information
- Related structures
- Hormones
- Receptors
-
Click to access the toolbox
To link to the content of EndoNet use the EndoNet ID that is given on the detail
pages in the format ENX0000, where X is a place holder for the type of
the component (e. g. R for receptor or C for anatomical structure).
As URL
for the linking append this ID to the detail page for this type of component.
For an hormone that would be:
http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000
It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like
http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000If the search pattern is unambigious the user is directed to the corresponding detail page.
Synonyms
preadipocyte, ,General information
Preadipocytes are present throughout adult life in adipose tissues and can proliferate and differentiate into mature adipocytesLinks to other resources
Cytomer | cy0044758 |
Related structures
Larger structures
Substructures
Secreted hormones
-
Hormone: VEGF-165
Influenced by:
- leptin receptor
in
preadipocyte
- Leptin induced VEGF mRNA expression in cultured pre-adipocytes but not in adipocytes. [1]
- leptin receptor
in
preadipocyte
Receptors
-
Receptor: leptin receptor
Influences:
-
Receptor: PRLR
Induced phenotype:
- differentiation of preadipocytes
- Prolactin induces differentiation of preadipocytes. Prolactin and its receptor play a role in differentiation and/or metabolism of pre-adipocytes and adipocytes. [2]
- differentiation of preadipocytes
-
Receptor: Lysophosphatidic acid receptor 1
Induced phenotype:
- negative regulation of fat cell differentiation
- LPA1 signaling appears to be antiadipogenic because stimulation of LPA1 signaling inhibits the differentiation of preadipocytes. This inhibitory effect is the result of the downregulation of PPARγ2. [3]
- positive regulation of cell motility
- The first indications that LPA is involved in adipogenesis were based on the observations that LPA is released by adipocytes, but not by preadipocytes, in vivo and in vitro, and LPA stimulates motility of preadipocytes through LPA1. [4]
- positive regulation of fat cell proliferation
- The first indications that LPA is involved in adipogenesis were based on the observations that LPA is released by adipocytes, but not by preadipocytes, in vivo and in vitro, and LPA stimulates proliferation of preadipocytes through LPA1. [5]
- positive regulation of glucose import
- It is indicated that LPA signaling, possibly through LPA1, regulates blood glucose levels by enhancing glucose uptake by adipocytes and thereby resulting in an LPA-induced glucose-lowering effect. [6]
- negative regulation of fat cell differentiation