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Details for anatomical structure: bergmann glia

EndoNet ID: ENC00549

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Synonyms

bergmann glia, ,

General information

Bergmann glia are astrocytes in the cerebellum that have their cell bodies in the Purkinje cell layer. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals.

Links to other resources

Cytomer cy0052320

Larger structures

    Substructures

      Secreted hormones

      • Hormone: ataxin-7

        • Bergmann glia-specific expression of mutant ataxin-7 was sufficient to produce ataxia and neurodegeneration. [1]

      Receptors

      • Receptor: ETB-R

      • Receptor: GLAST

        Induced phenotype:

        • neuronal hyperexcitability
          • Heterozygous mutation in GLAST leads to neuronal hyperexcitability that causes seizures, hemiplegia and episodic ataxia. [2]
        • termination of excitatory nerve signals
          • GLAST regulates the uptake of glutamate, important for the termination of excitatory signals and the maintenance of non-toxic concentrations. [3]
      Reference