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Details for anatomical structure: dorsal root ganglion

EndoNet ID: ENC00563

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Synonyms

dorsal root ganglion, dorsal root ganglia, spinal ganglion, Ganglion sensorium nervi spinalis

General information

Ganglia of dorsal roots of spinal nerves

Links to other resources

Cytomer cy0023703

Larger structures

    Substructures

      Secreted hormones

        Receptors

        • Receptor: Transient receptor potential cation channel subfamily V member 1

          Induced phenotype:

          • sensory perception of pain
            • VR1 is essential for the development of sensitization to thermal stimuli during inflammation but not for the normal sensation of noxious heat. [1]
        • Receptor: TrpV4-A

          Induced phenotype:

          • multicellular organismal water homeostasis
            • Blockers of TRPV4 Attenuate the Hypotonic Stimulus-Induced [Ca2+]i Increase in Nociceptors, this suppoprt the involvement of TRPV4 in nociceptor osmosensitivity.
            • TRPV4 is a transducer of osmotic stimulation in primary afferent nociceptive nerve fibers, and a transducer involved in inflammatory pain.
        • Receptor: trkC

          Induced phenotype:

          • proprioception
            • TrkC deficient mice display abnormal movements that are athetotic in nature and result in highly abnormal limb postures. This suggests a defect in proprioception, the sensory function that localizes the limbs in space. [2]
            • Neurotrophin signaling through trk receptors is important in the development and maintenance of the mammalian nervous system. [3]
            • Mice lacking trkC have a loss of DRG neurons, this defect might be amongst other responsible for the abnormal movements. [3]
        • Receptor: trkB

          Induced phenotype:

          • regulation of feeding behavior
            • TrkB deficient mice display a loss in lumbar dorsal root ganglia. [4]
            • TrkB may play a role in the complex interactions involved in feeding activity of newborn animals. [3]
            • Neurotrophin signaling through trk receptors is important in the development and maintenance of the mammalian nervous system. [3]
        • Receptor: trkA

          Induced phenotype:

          • thermoception
            • Neuroanatomical examinatio of the PNS of mice lacking trkA revealed extensive neuronal cell loss in trigeminal, dorsal root, and sympathetic ganglia. [5]
            • Mice lacking the trkA exhibit deficiencies in thermoception. [3]
            • Neurotrophin signaling through trk receptors is important in the development and maintenance of the mammalian nervous system. [3]
        Reference