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Details for anatomical structure: endothelial cell

EndoNet ID: ENC00600

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endothelial cell, cell of endothelial tissue, cell of endothelium, Endotheliozytus

General information

builds the simple squamous epithelium

Links to other resources

Cytomer cy0011455

Larger structures


      Secreted hormones

      • Hormone: 6-Keto-PGF1a

        • 6-keto-PGF1 alpha is produced and released by endothelial cells. [1]
      • Hormone: sVEGFR-2

        • Blood endothelial cells were identified as sources of plasma sVEGFR. [2]
      • Hormone: osteonectin

        • Osteoblasts, endothelial cells, megakaryocytes, vascular smooth muscle cells, chondrocytes, steroidogenic cells, and placental trophoblasts have been described to produce osteonectin. [3]
      • Hormone: nuclear factor from high endothelial venules

        • Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes [4]
      • Hormone: C-type natriuretic peptide


      • Receptor: bradykinin receptor B1

      • Receptor: CMKLR1

        • We have demonstrated the novel presence of ChemR23 in human ECs [5]

        Induced phenotype:

        • angiogenesis
          • Our data provide the first evidence of chemerin-induced endothelial angiogenesis. [5]
      • Receptor: integrin alphaV/beta3

        • The angiogenic integrins, αvβ3 and αvβ5, which are expressed on endothelial cells, are crucial for their survival [6]

        Induced phenotype:

        • endothelial cell adhesion
          • In this study, we show that purified CTGF protein promotes the adhesion of microvascular endothelial cells through the integrin receptor αvβ3. [7]
        • positive regulation of endothelial cell migration
          • CTGF stimulates the migration of microvascular endothelial cells in culture, also through an integrin-αvβ3-dependent mechanism. [7]
      • Receptor: Duffy

        • Duffy antigen is a transmembrane N-glycosylated protein present mainly on erythrocytes and endothelial cells. [8]

        Induced phenotype:

        • regulation of leukocyte migration
          • Duffy, expressed in endothelial cells, is a regulator of induced leukocyte trafficking [8]