Status
Please wait ...

Details for anatomical structure: endothelial cell

EndoNet ID: ENC00600

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

endothelial cell, cell of endothelial tissue, cell of endothelium, Endotheliozytus

General information

builds the simple squamous epithelium

Links to other resources

Cytomer cy0011455

Larger structures

  • brain
  • heart
  • lymph_node
  • breast
  • spleen
  • large_intestine
  • lung
  • D_cell_of_gastrointestinal_tract
  • muscle
  • adrenal_medulla
  • endocardium
  • uterus
  • immune_system
  • blood_vessel
  • liver
  • pancreas
  • pulmonary_vessels
  • small_intestine
  • eye
  • chorion
  • central_nerve_system_element
  • bone_marrow
  • skeleton_muscle
  • circulatory_system__hematopoietic_system
  • placenta
  • parts_of_human_body
  • digestive_system
  • adrenal_gland
  • nerve
  • trachea
  • mammary_gland

Substructures

    Secreted hormones

    • Hormone: 6-Keto-PGF1a

      • 6-keto-PGF1 alpha is produced and released by endothelial cells. [1]

    • Hormone: sVEGFR-2

      • Blood endothelial cells were identified as sources of plasma sVEGFR. [2]

    • Hormone: osteonectin

      • Osteoblasts, endothelial cells, megakaryocytes, vascular smooth muscle cells, chondrocytes, steroidogenic cells, and placental trophoblasts have been described to produce osteonectin. [3]

    • Hormone: nuclear factor from high endothelial venules

      • Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes [4]

    • Hormone: C-type natriuretic peptide

    Receptors

    • Receptor: bradykinin receptor B1

    • Receptor: CMKLR1

      • We have demonstrated the novel presence of ChemR23 in human ECs [5]

      Induced phenotype:

      • angiogenesis
        • Our data provide the first evidence of chemerin-induced endothelial angiogenesis. [5]

    • Receptor: integrin alphaV/beta3

      • The angiogenic integrins, αvβ3 and αvβ5, which are expressed on endothelial cells, are crucial for their survival [6]

      Induced phenotype:

      • endothelial cell adhesion
        • In this study, we show that purified CTGF protein promotes the adhesion of microvascular endothelial cells through the integrin receptor αvβ3. [7]
      • positive regulation of endothelial cell migration
        • CTGF stimulates the migration of microvascular endothelial cells in culture, also through an integrin-αvβ3-dependent mechanism. [7]

    • Receptor: Duffy

      • Duffy antigen is a transmembrane N-glycosylated protein present mainly on erythrocytes and endothelial cells. [8]

      Induced phenotype:

      • regulation of leukocyte migration
        • Duffy, expressed in endothelial cells, is a regulator of induced leukocyte trafficking [8]
    Reference