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Details for messenger / hormone: androstenedione

EndoNet ID: ENH00007

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Synonyms

  • androstenedione
  • delta4-A
  • 4-androstene-3,17-dione
  • AD
  • A4
  • androtex

General information

  • Depending on the tissue type (testis, ovary or adrenal cortex), androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL. [1]
  • Androstenedione is the immediate precursor of testosterone. [2]
  • Dihydrotestosterone, stanozolol, androstenedione and dehydroepiandrosterone sulphate inhibit leptin secretion in female but not in male samples of omental adipose tissue in vitro: lack of effect of testosterone. [3]

Classification

Hormone function

  • homeostasis
    • hormone precursor

    Chemical classification

    • hormone
      • not genome-encoded
        • sterol lipids
          • steroids
            • androgens

      Composition

      KEGG C00280

      Links to other resources

      KEGG C00280
      LIPID MAPS LMST02020007
      LipidBank SST0028

      • Anatomical structure: theca_cell

        • The delivery of LH to the theca interstitial cell leads to the synthesis and secretion of androstenedione. [4]
        • synthesized from dehydroepiandrosterone and then converted to testosterone by the enzyme 17{beta}-hydroxysteroid dehydrogenase or to estrone by the aromatase enzyme complex [5]
        • produced in the adrenal glands and the gonads

        Influenced by:

        • LHCGR-1
          in theca_cell
          • androstenedione is released into the blood by theca cells to provide androstenedione substrate for estrogen production in granulosa cells
        • ER-beta
          in theca_lutein_cell
          • Estradiol treatment inhibits hCG stimulated production of androstenedione by theca cells. [6]

      • Anatomical structure: cell_of_adrenal_gland_zona_reticularis

        Influenced by:

        • ACTH receptor
          in cell_of_adrenal_gland_zona_reticularis
        • IL-6R
          in cell_of_adrenal_gland_zona_reticularis

      • Anatomical structure: adrenal_cortex

      • Anatomical structure: testis

      Targets

      Cell
      No records found.
      Reference