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Details for messenger / hormone: corticosterone

EndoNet ID: ENH00018

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Synonyms

  • corticosterone
  • B
  • 11beta,21-dihydroxy-4-pregnene-3,20-dione
  • 4-Pregnene-11b,21-diol-3,20-dione

General information

  • Corticosterone (cortisol in humans), a glucocorticoid hormone released into circulation in response to psychological stress via the hypothalamic-pituitary-adrenal axis, can undermine primary and memory CD8(+) cytotoxic T lymphocyte (CTL) responses. [1]
  • See cortisol.
  • Low-dose corticosterone enhances the amplitude and improved gating of evoked potentials without affecting the intensity function. [2]

Classification

Hormone function

  • homeostasis
    • hormone precursor

    Chemical classification

    • hormone
      • not genome-encoded
        • sterol lipids
          • steroids
            • glucocorticoids

      Composition

      KEGG C02140

      Links to other resources

      KEGG C02140
      LIPID MAPS LMST02030092
      LipidBank SST0168
      • Anatomical structure: cell_of_adrenal_gland_zona_fasciculata

        Influenced by:

        • ACTH receptor
          in cell_of_adrenal_gland_zona_fasciculata
        • IL-6R
          in cell_of_adrenal_gland_zona_fasciculata
      • Anatomical structure: adrenal_cortex

      Targets

      Cellglucocorticoid receptormineralcorticoid receptor
      brain Present
      cardiac myocyte Present
      cerebellum Present
      colon Present
      eosinophil granulocyte Present
      epidermis Present
      epithelial cell Present
      Phenotypes
      • multicellular organismal water homeostasis
      heart Present
      hepatocyte Present
      Influences
      • IGF-1
      • CBG
      hippocampus Present
      hypothalamus Present
      Influences
      • CRH
      • orexin-A
      • CRH
      kidney Present
      Present
      Phenotypes
      • Hypoaldosteronism
      • Primary Hyperaldosteronism
      lung Present
      macrophage Present
      Phenotypes
      • hypertension
      • abdominal obesity-metabolic syndrome
      • negative regulation of immune response
      • osteoporosis
      • atherosclerosis
      Present
      Phenotypes
      • positive regulation of immune response
      • fibrosis
      • production of molecular mediator involved in inflammatory
      • atherosclerosis
      • hypertension
      major salivary glands Present
      microglial cell in central nervous system Present
      Phenotypes
      • negative regulation of immune response
      Present
      Phenotypes
      • positive regulation of immune response
      nasal mucosa Present
      neutrophil granulocyte Present
      peripheral blood mononuclear cell (PBMC) Present
      pituitary gland of diencephalon Present
      skeleton muscle Present
      spleen Present
      Present
      thymus Present
      Reference