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Details for messenger / hormone: cortisone

EndoNet ID: ENH00020

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Synonyms

  • cortisone
  • E
  • 17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione
  • 17,21-dihydroxy-4-pregnene-3,11,20-trione
  • 17-Hydroxy-11-dehydrocorticosterone
  • 11-Dehydro-17-hydroxycorticosterone
  • D4-Pregnene-17a,21-diol-3,11,20-trione

General information

  • 11beta-Hydroxysteroid dehydrogenase type 1-driven cortisone reactivation regulates plasminogen activator inhibitor type 1 in adipose tissue of obese women. [1]
  • 11 beta-Hydroxysteroid dehydrogenase type 2 plays a crucial role in converting hormonally active cortisol to inactive cortisone, thereby conferring specificity on the mineralocorticoid receptor. [2]
  • 11beta-HSD type 1 principally performs the reverse reaction activating cortisol from inactive cortisone in the liver and adipose tissue. [3]

Classification

Hormone function

  • CNS function
    • stress response

    Chemical classification

    • hormone
      • not genome-encoded
        • sterol lipids
          • steroids
            • glucocorticoids

      Composition

      KEGG C00762

      Links to other resources

      KEGG C00762
      LIPID MAPS LMST02030090
      LipidBank SST0042

      • Anatomical structure: cell_of_adrenal_gland_zona_fasciculata

        Influenced by:

        • ACTH receptor
          in cell_of_adrenal_gland_zona_fasciculata
        • IL-6R
          in cell_of_adrenal_gland_zona_fasciculata

      Targets

      Cellglucocorticoid receptor
      brain Present
      colon Present
      eosinophil granulocyte Present
      heart Present
      hepatocyte Present
      Influences
      • ↑ IGF-1
      • ↓ CBG
      hypothalamus Present
      Influences
      • ↓ CRH
      • ↓ orexin-A
      • ↓ CRH
      kidney Present
      lung Present
      macrophage Present
      Phenotypes
      • hypertension
      • abdominal obesity-metabolic syndrome
      • negative regulation of immune response
      • osteoporosis
      • atherosclerosis
      microglial cell in central nervous system Present
      Phenotypes
      • negative regulation of immune response
      nasal mucosa Present
      neutrophil granulocyte Present
      peripheral blood mononuclear cell (PBMC) Present
      pituitary gland of diencephalon Present
      skeleton muscle Present
      spleen Present
      thymus Present
      Reference