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Details for messenger / hormone: IGF

EndoNet ID: ENH00030

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Synonyms

  • IGF
  • insulin like growth factor

General information

  • Osteoblasts synthesize IGF-I and IGF-II which have mitogenic effects on bone cells. [1]
  • The synthesis of IGFs in osteoblasts is down-regulated by many locally produced growth factors, particularly transforming growth factor beta (TGF-beta) and cortisol, and this probably accounts for the osteoporotic effects of this steroid, whereas PTH is stimulatory. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • insulin family

      Links to other resources

      • Anatomical structure: osteoblast

      Targets

      CellIGF-1R
      acidophil somatotroph cell of anterior pituitary Present
      Phenotypes
      • cell growth
      • positive regulation of cell proliferation
      • negative regulation of apoptosis
      • transformation
      Influences
      • GH
      adrenal cortex Present
      chondrocyte Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      Influences
      • annexin A2
      lung Present
      Influences
      • amphiregulin
      microvascularendothelial cell Present
      osteoblast Present
      Reference