Status
Please wait ...

Details for messenger / hormone: MSH

EndoNet ID: ENH00041

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • MSH
  • melanocortin
  • melanocyte-stimulating hormone
  • melanocyte stimulating hormone

General information

  • MSH increases the pigmentation of skin by increasing melanin production in melanocytes.

Classification

Hormone function

  • development and growth
    • environment adaptation

    Chemical classification

    • hormone
      • genome-encoded

    Links to other resources

    • Anatomical structure: cell_of_intermediate_pituitary

      • http://www.gesundheit.de/roche/ro22500/r24123.000.html [1]

      Influenced by:

      • MC1R
        in melanocyte
      • MC1R
        in skin
      • melatonin 1 receptor
        in hypothalamus
      • dopamine receptor D2
        in cell_of_intermediate_pituitary
        • The secretion of melanocyte-stimulating hormone (MSH) by intermediate lobe cells is under the negative influence of the hypothalamus. The predominant role of the tubero-hypophyseal dopaminergic neurons in the inhibitory control of MSH secretion has been demonstrated in mammals. [2]
        • Dopamine (in perifusion model) was responsible for a dose-related inhibition of MSH secretion. [3]
      • TRH-R
        in cell_of_intermediate_pituitary
        • In amphibians, TRH stimulates MSH release in vitro and that the action of TRH is not mediated via an inhibition of the release of endogenous dopamine. [4]
        • TRH reverses the inhibitory effect of dopamine on MSH secretion. The effects of TRH and dopamine are additive. Thus, the intracellular events associated with TRH-induced stimulation and dopamine-induced inhibition of MSH release are not linked together. [3]
    • Anatomical structure: basophil_corticotroph_cell_of_anterior_pituitary

    Targets

    CellACTH receptormelanocortin receptor 3melanocortin receptor 5melanocortin-4 receptor
    adipose tissue Present
    Influences
    • interleukin 6
    Present
    Influences
    • interleukin 6
    Present
    Influences
    • leptin
    adrenal cortex Present
    Phenotypes
    • Cushing syndrome
    • Familial glucocorticoid deficiency type I
    • Glucocorticoid remediable aldosteronism
    • Adrenocortical carcinoma
    • Addison disease
    arcuate nucleus of hypothalamus Present
    Phenotypes
    • negative regulation of appetite
    Present
    Phenotypes
    • negative regulation of appetite
    cell of adrenal gland zona fasciculata Present
    Influences
    • cortisone
    • cortisol
    • corticosterone
    cell of adrenal gland zona glomerulosa Present
    Influences
    • aldosterone
    cell of adrenal gland zona reticularis Present
    Influences
    • dehydro-3-epiandrosterone
    • testosterone
    • androstenedione
    epithelial cell Present
    hair follicle Present
    Phenotypes
    • cellular response to cortisol stimulus
    heart Present
    melanocyte Present
    Phenotypes
    • pigmentation
    paraventricular nucleus of hypothalamus Present
    Phenotypes
    • promotion of positive energy balance
    • negative regulation of appetite
    • obesity
    Present
    Phenotypes
    • promotion of positive energy balance
    • negative regulation of appetite
    • obesity
    sebaceous glands Present
    Phenotypes
    • sebogenesis
    • sebaceous gland development
    testis Present
    Phenotypes
    • androgen biosynthetic process
    Influences
    • testosterone
    Present
    Present
    thymic epithelial cell Present
    Influences
    • Thymulin
    Reference