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Details for messenger / hormone: vitamin D3

EndoNet ID: ENH00058

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  • vitamin D3
  • cholecalciferol
  • calciol
  • (5Z,7E)-(3S)-9,10-seco-5,7,10(19)-cholestatrien-3-ol

General information

  • Vitamin D3 increases the phagocytic potential and spontaneous lymphoproliferative response but brings down the antigen-induced response in normals. [1]
  • Vitamin D3 plays an anticonvulsant role in the brain and influences the efficacy of antiepileptic drugs. [2]
  • Vitamin D itself is a prohormone that is metabolically converted to the active metabolite, 1,25-dihydroxyvitamin D [1,25(OH)(2)D]. [3]


Hormone function

  • homeostasis
    • ion flow control

    Chemical classification

    • hormone
      • not genome-encoded
        • sterol lipids
          • secosteroids


      KEGG C05443

      Links to other resources

      LIPID MAPS LMST03020001
      LipidBank VVD0237
      • Anatomical structure: keratinocyte

        • The main source of vitamin D is its synthesis in human skin. 7-Dehydrocholesterol converts into cholecalciferol (vitamin D3) as a result of UV radiation. [4]
        • The major source of vitamin D (D3 cholecalciferol and D2 ergocalciferol) is synthesis from 7-dehydrocholesterol in the keratinocytes of the skin. [5]


      No records found.