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Details for messenger / hormone: bradykinin

EndoNet ID: ENH00062

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Synonyms

  • bradykinin
  • kallidin 9
  • kallidin I
  • BK

General information

  • The pro-inflammatory effects of bradykinin is mediated by at least two receptors: B2 and B1. The B2 subtype is expressed constitutively and the B1 receptor is induced following tissue inflammation and damage. The endogenous ligand for the B1 receptor is des-arg9BK, a cleavage product of the activity of carboxypeptidase on BK. Activation of B1 receptors produces a range of pro-inflammatory effects including oedema, pain and promotion of blood-borne leukocyte trafficking. [1]
  • Bradykinin and its biologically active metabolite des-Arg9 bradykinin (DABK), are produced at sites of inflammation and are important inflammatory mediators. [2]
  • Bradykinin is a 9 amino acid peptide chain. It is processed from a kininogen precursor by kallikreins.
  • Bradykinin stimulates vasodilatation and endothelial cell proliferation. [3]

Classification

Hormone function

  • homeostasis
    • cardiovascular control

    Chemical classification

    • hormone
      • genome-encoded
        • kinins

      Composition

      isoform HMW

      Sequence 
      RPPGFSPFR
      UniProt P01042-1
      KEGG C00306

      Links to other resources

      UniProt P01042
      Ensembl ENST00000447445
      KEGG hsa:3827

      • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

      • Anatomical structure: blood_vessel

      Targets

      Cellbradykinin receptor B1bradykinin receptor B2
      endothelial cell Present
      neutrophil granulocyte Present
      Phenotypes
      • Neutrophil chemotaxis
      osteoblast Present
      Influences
      • ↑ PGE2
      • ↑ PGI2
      		Present
      Influences
      • ↑ interleukin 6
      • ↑ PGE2
      • ↑ PGI2
      Reference