Status
Please wait ...

Details for messenger / hormone: cholecystokinin

EndoNet ID: ENH00063

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • (1-49)-CCK58
  • cholecystokinin
  • CCK
  • pancreozymin

General information

  • Cholecystokinin (CCK) IS a regulatory peptide that acts via two receptor subtypes, CCK1-R and CCK2-R. [1]
  • CCK, similar to other peptides modulating food intake (e.g., neuropeptide Y, leptin, and orexins), is also able to regulate the function of the hypothalamo-pituitary-adrenal axis, acting on both its central and peripheral branches. [2]
  • CCK enhances glucocorticoid secretion from zona fasciculata-reticularis cells via an indirect mechanism mainly involving the CCK2-R-mediated stimulation of corticotropin-releasing hormone-dependent ACTH release. [2]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • gastrointestinal hormones

    Composition

    Sequence
    QPVPPADPA GSGLQRAEE APRRQLRVS 
    QRTDGESRA HLGALLARY IQQARKAPS 
    GRMSIVKNL QNLDPSHRI SDRDYMGWM 
    DFGRRSAEE YEYPS

    Links to other resources

    UniProt P06307
    Ensembl ENST00000434608
    KEGG hsa:885
    • Anatomical structure: APUD_amine_precursor_uptake_and_decarboxylation_cell

      Influenced by:

      • CB1
        in adrenal_gland
        • Activation of presynaptic CB1 receptor leads to the inhibition of neurotransmitter release, e.g. cholecystokinin [3]
    • Anatomical structure: alpha_cell_of_islet_of_Langerhans

    • Anatomical structure: central_nerve_system_element

    • Anatomical structure: neuron

    • Anatomical structure: nucleus_accumbens

      Influenced by:

      • 5-HT3 receptor
        in frontal_lobe
        • 5-HT mediated activation of 5-HT-3 receptors enhance the release of cholecystokinin in synaptosomes of the rat nucleus accumbens and cerebral cortex. [4]

    Targets

    CellCCK-1CCK-2
    alpha cell of islet of Langerhans Present
    Influences
    • glucagon
    cell of adrenal gland zona glomerulosa Present
    Influences
    • aldosterone
    Present
    Influences
    • aldosterone
    colon Present
    Phenotypes
    • induction of smooth muscle contraction
    Present
    Phenotypes
    • induction of smooth muscle contraction
    D cell Present
    Influences
    • somatostatin
    D cell of gastrointestinal tract Present
    Influences
    • somatostatin
    • gastrin
    digestive system Present
    Influences
    • somatostatin
    enterochromaffin like cell Present
    Phenotypes
    • positive regulation of smooth muscle proliferation
    Influences
    • histamine
    gallbladder Present
    Phenotypes
    • gastro-intestinal system smooth muscle contraction
    hypothalamus Present
    Phenotypes
    • negative regulation of appetite
    Present
    Phenotypes
    • negative regulation of appetite
    intestinal smooth muscle cell Present
    Phenotypes
    • induction of smooth muscle contraction
    Present
    Phenotypes
    • induction of smooth muscle contraction
    mucosa of small intestine Present
    Present
    neuron Present
    oxyntic cell of gastric gland Present
    Present
    Phenotypes
    • positive regulation of gastric acid secretion
    pancreas Present
    Phenotypes
    • mitogen activity
    • positive regulation of pancreatic juice secretion
    Influences
    • pancreatic alpha-amylase
    smooth muscle Present
    stomach Present
    Phenotypes
    • inhibition of gastric emptying
    zymogenic cell of gastric gland Present
    Reference