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Details for messenger / hormone: CRH

EndoNet ID: ENH00064

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Synonyms

  • CRH
  • corticoliberin
  • CRF
  • corticotropin-releasing factor
  • corticotropin-releasing hormone

General information

  • Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. [1]
  • Corticotropin-releasing hormone regulates IL-6 expression during inflammation. [2]
  • Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes. [3]
  • CRH modulates important functional hair growth parameters in vitro (hair shaft elongation, catagen induction, hair keratinocyte proliferation, melanin production). [4]
  • CRH, the principal neuropeptide regulator of pituitary ACTH secretion, is also expressed in placenta. [5]
  • CRH also controls the processing of the prohormone POMC into various POMC-derived neuropeptide hormones, such as ACTH and alpha-MSH, by prohormone convertases (PC1 or PC2). [4]
  • In Alzheimer's disease (AD) there are dramatic reductions in the content of corticotropin releasing factor (CRF), reciprocal increases in CRF receptors, and morphological abnormalities in CRF neurons in affected brain areas. [6]

Classification

Hormone function

  • homeostasis
    • further hormone secretion

    Chemical classification

    • hormone
      • genome-encoded
        • corticotrophin-releasing factor family

      Composition

      Sequence
      SEEPPISLD LTFHLLREV LEMARAEQL 
      AQQAHSNRK LMEII

      Links to other resources

      UniProt P06850
      Ensembl ENST00000276571
      KEGG hsa:1392
      • Anatomical structure: paraventricular_nucleus_of_hypothalamus

        • CRH neurons in the PVN decrease food intake. [7]

        Influenced by:

        • leptin receptor
          in paraventricular_nucleus_of_hypothalamus
          • after leptin administration CRH genexpression have been noted after 6h and 5d [8]
        • glucocorticoid receptor
          in hypothalamus
          • Glucocorticoid/Cortisol binding to GR in the hypothalamus inhibits secretion of CRH [9]
        • CRF-R1
          in paraventricular_nucleus_of_hypothalamus
          • CRF may modulate its own biosynthesis as well as that of its type-1 receptor through an ultra-short positive feedback loop. [10]
        • glucocorticoid receptor
          in hypothalamus
          • The reduction in CRF mRNA expression in the parvocellular PVN in uncontrolled diabetes most probably depends on the levels of plasma corticosterone. Increased corticosterone levels were accompanied with a decrease in parvocellular CRF expression. [11]
      • Anatomical structure: hair_follicle

      • Anatomical structure: alpha_cell_of_islet_of_Langerhans

        • Co-localization of CRH, GIP, PP and CCK in A-cells was determined by immunocytochemistry. S.456 [12]
      • Anatomical structure: D_cell

      Targets

      CellCRF-R1CRF-R2
      adrenal gland Present
      Phenotypes
      • negative regulation of immune response
      amygdaloid body Present
      brain Present
      Influences
      • antidiuretic hormone
      brain stem Present
      cell of adrenal gland zona fasciculata Present
      Present
      cell of adrenal gland zona reticularis Present
      Present
      cell of endometrium of uterus Present
      cell of intermediate pituitary Present
      central nerve system element Present
      Phenotypes
      • regulation of HPA axis
      cerebellar cortex Present
      eccrine gland Present
      epidermis Present
      epithelial hair matrix cell Present
      hair follicle Present
      Phenotypes
      • hair follicle maturation
      • positive regulation of transcription
      Influences
      • cortisol
      heart Present
      Present
      hippocampus Present
      Present
      isocortex Present
      kidney Present
      lung Present
      Present
      mast cell Present
      Phenotypes
      • mast cell activation
      Influences
      • histamine
      • VEGF-165
      ovary Present
      paraventricular nucleus of hypothalamus Present
      Phenotypes
      • hyperactvity of HPA axis
      • hyperdipsia
      • hyperphagia
      Influences
      • CRH
      pituitary gland of diencephalon Present
      Present
      Influences
      • ACTH
      placenta Present
      Present
      sebaceous glands Present
      skeleton muscle Present
      Present
      skin Present
      stomach Present
      Present
      substantia nigra Present
      testis Present
      thalamus Present
      ventromedial nucleus of hypothalamus Present
      Phenotypes
      • hyperactivity of HPA axis
      • hyperphagia
      • hyperdipsia
      Influences
      • insulin
      Reference