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Details for messenger / hormone: dehydro-3-epiandrosterone

EndoNet ID: ENH00065

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Synonyms

  • dehydro-3-epiandrosterone
  • DHEA
  • DHA
  • 3beta-hydroxyandrost-5-en-17-one
  • dehydroepiandrosterone
  • dehydroisoandrosterone

General information

  • DHEA can be converted to TESTOSTERONE, ANDROSTENEDIONE, ESTRADIOL and ESTRONE. [1]
  • Produced by the adrenal cortex, also produced in small quantities in the testis and the ovary. [1]
  • DHEA in monocyte-derived macrophages is converted in delta 5 steroids, delta 4 steroids and estrogens. [2]
  • DHEA supplementation benefites in two specific groups of women: those with the lowest circulating levels of DHEA; and those for whom osteoporosis is a particular problem. [3]
  • The Section of DHEA is relate to stress, central nervous system function and psychiatric disorders, insulin sensitivity, immunological function, and cardiovascular disorders. [4]
  • DHEA exerts chemopreventive effects in multiorgans with the exception of the DHEA-treated liver case. [5]
  • DHEA suppresses inducible nitric oxide synthase gene expression in lipopolysaccharide-stimulated BV-2 cells. [6]

Classification

Hormone function

  • homeostasis
    • hormone precursor

    Chemical classification

    • hormone
      • not genome-encoded
        • sterol lipids
          • steroids
            • androgens

      Composition

      KEGG C01227

      Links to other resources

      KEGG C01227
      LIPID MAPS LMST02020021
      LipidBank SST0185

      • Anatomical structure: cell_of_adrenal_gland_zona_reticularis

        Influenced by:

        • ACTH receptor
          in cell_of_adrenal_gland_zona_reticularis
        • IL-6R
          in cell_of_adrenal_gland_zona_reticularis

      • Anatomical structure: adrenal_cortex

      • Anatomical structure: ovary

      • Anatomical structure: testis

      Targets

      Cell
      No records found.
      Reference