Status
Please wait ...

Details for messenger / hormone: EGF

EndoNet ID: ENH00067

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • EGF
  • epidermal growth factor
  • urogastrone
  • hEGF

General information

  • Urogastrone or human epidermal growth factor promotes cellular proliferation and inhibits gastric acid secretion. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • EGF family

      Composition

      epidermal growth factor

      Sequence 
      NSDSECPLS HDGYCLHDG VCMYIEALD 
KYACNCVVG YIGERCQYR DLKWWELR
      UniProt P01133

      Links to other resources

      UniProt P01133
      Ensembl ENST00000265171
      KEGG hsa:1950

      • Anatomical structure: kidney

      • Anatomical structure: colon

      • Anatomical structure: aorta

      • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

      • Anatomical structure: epithelial_cell

      • Anatomical structure: stromal_fibroblast

      • Anatomical structure: epithelial_cell_of_oviduct

      • Anatomical structure: osteoblast

      • Anatomical structure: keratinocyte

      • Anatomical structure: blood_vessel

      • Anatomical structure: smooth_muscle

      • Anatomical structure: duodenum

      • Anatomical structure: submandibular_gland

      • Anatomical structure: duodenal_glands

      Targets

      CellADAM10EGFR isoform a
      digestive system Present
      epithelial cell Present
      epithelial cell with microvilli Present
      Influences
      • ↑ mucin-2
      G cell Present
      Influences
      • ↑ gastrin
      hepatocyte Present
      Influences
      • ↑ IL-1 alpha
      • ↑ IL-1 beta
      lipocyte of liver Present
      Phenotypes
      • positive regulation of cell proliferation and apotosis
      neutrophil granulocyte Present
      Influences
      • ↑ IL-8
      placenta Present
      Reference