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Details for messenger / hormone: FGF-1 isoform 1

EndoNet ID: ENH00072

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Synonyms

  • FGF-1 isoform 1
  • acidic fibroblast growth factor isoform 1
  • aFGF isoform 1
  • beta-endothelial cell growth factor
  • ECGF-beta
  • FGFA
  • fibroblast growth factor 1
  • HBGF-1
  • heparin-binding growth factor 1
  • acidic FGF isoform 1
  • FGF1 full lenght

General information

  • Fibroblast growth factor-1 induces phosphofructokinase, fatty acid synthase and Ca(2+)-ATPase mRNA expression in NIH 3T3 cells. [1]
  • The expression of aFGF is highest during the late stages of hepatic morphogenesis in newborn animals as well as during hepatic differentiation in adult liver. [2]
  • FGF-1 is a heparin-independent mitogen for rat hepatocytes. [3]
  • Angiogenic , involved in wound healing.
  • Cytokine which plays a role in the differentiation of the hepatic endoderm. [4]
  • Different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis. [5]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • heparin-binding growth factors

      Composition

      • Monomer, forms a ternary complex containing 2 molecules each of FGFR2 and FGF1 for 1 heparin molecule. [6]
      Sequence
      FNLPPGNYK KPKLLYCSN GGHFLRILP 
      DGTVDGTRD RSDQHIQLQ LSAESVGEV 
      YIKSTETGQ YLAMDTDGL LYGSQTPNE 
      ECLFLERLE ENHYNTYIS KKHAEKNWF 
      VGLKKNGSC KRGPRTHYG QKAILFLPL 
      PVSSD

      Links to other resources

      UniProt P05230
      Ensembl ENST00000441680
      KEGG hsa:2246
      • Anatomical structure: brain_stem

      • Anatomical structure: acinar_cell_of_pancreas

      • Anatomical structure: blood_vessel

      • Anatomical structure: astrocyte

      • Anatomical structure: glial_cell_of_central_nervous_system

      • Anatomical structure: neuron

      • Anatomical structure: cell_of_endometrium_of_uterus

      • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

      • Anatomical structure: fibroblast

      • Anatomical structure: mammary_gland

      • Anatomical structure: smooth_muscle

      • Anatomical structure: T-lymphocyte

      Targets

      CellESL-1FGF-BPFGFR-1FGFR-2FGFR-3FGFR-4
      adrenal cortex Present
      Present
      brain Present
      Phenotypes
      • Kallmann syndrome 2
      • olfactory bulb morphogenesis
      cardiac muscle Present
      Phenotypes
      • regulation of cell proliferation
      Present
      Phenotypes
      • regulation of cell proliferation
      cerebral cortex Present
      Phenotypes
      • regulation of neuron differentiation
      chondrocyte Present
      Present
      Phenotypes
      • endochondral ossification
      endocardium Present
      hair follicle Present
      hepatocyte Present
      lymphocyte Present
      Influences
      • FGF-3
      skin Present
      Reference