Status
Please wait ...

Details for messenger / hormone: FGF-2

EndoNet ID: ENH00073

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • bFGF
  • basic fibroblast growth factor
  • basic FGF
  • FGF-2
  • FGF2
  • fibroblast growth factor 2
  • HBGF-2
  • prostatropin
  • heparin-binding growth factor 2
  • FGFB

General information

  • FGF2 works in differentiation of hepatic endoderm. [1]
  • FGF2-induced chromatin remodeling regulates CNTF-mediated gene expression and astrocyte differentiation. [2]
  • Fibroblast growth factor 2 facilitates the differentiation of transplanted bone marrow cells into hepatocytes. [3]
  • Basic fibroblast growth factor (bFGF) is known to stimulate the regeneration of a number of tissues including cartilage, nerve, skin, liver, and blood vessel [4]
  • Involved in vasculogenesis, angiogenesis, hematopoiesis, neuron survival, and wound healing.

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • heparin-binding growth factors

      Composition

      processed

      Sequence
      MVGVGGGDV EDVTPRPGG CQISGRAAR 
      GCNGIPGAA AWEAALPRR RPRRHPSVN 
      PRSRAAGSP RTRGRRTEE RPSGSRLGD 
      RGRGRALPG GRLGGRGRG RAPERVGGR 
      GRGRGTAAP RAAPAARGS RPGPAGTMA 
      AGSITTLPA LPEDGGSGA FPPGHFKDP 
      KRLYCKNGG FFLRIHPDG RVDGVREKS 
      DPHIKLQLQ AEERGVVSI KGVCANRYL 
      AMKEDGRLL ASKCVTDEC FFFERLESN 
      NYNTYRSRK YTSWYVALK RTGQYKLGS 
      KTGPGQKAI LFLPMSAKS

      Links to other resources

      UniProt P09038
      Ensembl ENST00000394350
      KEGG hsa:2247
      • Anatomical structure: pancreas

        • Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates. [5]
      • Anatomical structure: heart

        • Cardiac mesoderm expresses fibroblast growth factors (FGFs) 1, 2, and 8, and causes the foregut endoderm to develop into the liver. [6]
      • Anatomical structure: cardiac_myocyte

        • FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes. [7]
      • Anatomical structure: astroglia

        • FGF-2 is expressed by astrocytes. [8]
      • Anatomical structure: acinar_cell_of_pancreas

      • Anatomical structure: fat_cell

      • Anatomical structure: smooth_muscle_cell

      • Anatomical structure: astrocyte

      • Anatomical structure: hematopoietic_stem_cell

      • Anatomical structure: T-lymphocyte

      • Anatomical structure: vascularendothelial_cell

      • Anatomical structure: cerebellum

      • Anatomical structure: eye

      • Anatomical structure: fibroblast

      • Anatomical structure: keratinocyte

      • Anatomical structure: mast_cell

      • Anatomical structure: macrophage

      • Anatomical structure: mammary_gland

      • Anatomical structure: melanocyte

      • Anatomical structure: ovarian_follicle_cell

      • Anatomical structure: prostate

      • Anatomical structure: skin

      • Anatomical structure: fibroblast

      • Anatomical structure: connective_tissue_of_prostate_gland

      • Anatomical structure: mast_cell

      • Anatomical structure: fibroblast

      Targets

      CellESL-1FGF-BPFGFR-4fibroblast growth factor receptor-like 1
      dentate gyrus of hippocampus Present
      hair follicle Present
      heart Present
      Phenotypes
      • valvulogenesis
      hepatocyte Present
      kidney Present
      lung Present
      lymphocyte Present
      Influences
      • FGF-3
      skin Present
      Reference