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Details for messenger / hormone: IGF-2

EndoNet ID: ENH00084

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Synonyms

  • IGF-2
  • insulin-like growth factor II
  • IGF-II
  • somatomedin A
  • IGF2
  • insulin-like growth factor 2

General information

  • Does not circulate in a free form but rather attached to the binding proteins. [1]
  • Osteoblasts synthesize IGF-I and IGF-II which have mitogenic effects on bone cells. [2]
  • Enigmatic hormone produced in liver, and in some extrahepatic tissues, that is related to IGF-I. [1]
  • Virtually all IGF-2 in serum is complexed to IGFBPs. [3]
  • In normal adult serum, 75% to 80% of the IGF peptides are carried in a ternary complex consisting of one molecule of IGF plus one molecule of IGFBP-3 plus one molecule of an 88-kd protein termed the acid-labile subunit (ALS). [4]
  • The half-life of IGF peptides from approximately 10 minutes for IGF alone is extended to 1-2 hours for IGF in the IGF-IGFBP-3 binary complex to 12-15 hours for IGF in the ternary complex. [5]
  • Under most conditions, the IGFBPs appear to inhibit IGF action, presumably by competing with IGF receptors for binding IGF peptides. [6]
  • Strong mitogen for hepatocytes during liver development, also detected inhepatocellular carcinoma and hepatoma cells. [7]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • insulin family

      Links to other resources

      UniProt P01344
      Ensembl ENST00000434045
      KEGG hsa:3481
      • Anatomical structure: beta_cell_of_islet_of_Langerhans

        • Co-localization of IGF-2 in B-cells was determined by immunocytochemistry. S.456 [8]
      • Anatomical structure: osteoblast

        • IGF-1 and IGF-2 are expressed by osteoblasts and act locally to stimulate both bone formation and resorption. [9]

      Targets

      CellIGF-2Rinsulin receptor
      adrenal cortex Present
      alpha cell of islet of Langerhans Present
      Influences
      • glucagon
      arcuate nucleus of hypothalamus Present
      Influences
      • NPY
      • AGRP
      • alpha-MSH
      • insulin
      basophil corticotroph cell of anterior pituitary Present
      Phenotypes
      • tertiary adrenal insufficiency
      Influences
      • ACTH
      • lipotropin beta
      beta cell of islet of Langerhans Present
      Phenotypes
      • Diabetes mellitus type 2
      • Leprechaunism
      • Diabetes mellitus type 1
      • Maturity onset diabetes of the young
      • Insulimona
      • Hypoglycemia
      Influences
      • insulin receptor substrate 1
      • insulin
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      Influences
      • annexin A2
      • NO
      fat cell Present
      Influences
      • VEGF-165
      • IL-8
      • leptin
      heart Present
      skeleton muscle Present
      Reference