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Details for messenger / hormone: angiotensin II

EndoNet ID: ENH00097

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Synonyms

  • angiotensin II
  • angiotensin 2
  • ANG 2
  • ANG ll
  • ANG2

General information

  • Ang II can induce apoptosis. [1]
  • Angiotensin II stimulates prostacyclin production and release, which in turn is a factor inducing the differentiation of preadipocytes to mature adipocytes. [2]
  • Ang II, acting on the AT1 and AT2 receptors in mammalian cells, is the vasoactive component of the renin-angiotensin system (RAS). [3]
  • Ang II, derived from AGT secreted by mature adipocytes, may act in a paracrine way to induce the production and release of PGI 2 , thereby promoting adipogenic differentiation of pre-adipocytes into mature adipocytes. [3]
  • Macrophage adhesion and accumulation are prevented by NO, which is counterbalanced by angiotensin II. [2]
  • THe activation of the angiotensin system plays an important role in the pathophysiology of renal disease with glycogen storage disease type Ia. [4]
  • THe activation of the renin-angiotensin system contributes to oxidative stress and endothelial dysfunction after endotoxin. [5]
  • The octapeptide ANG II is formed from the plasma protein angiotensinogen by the sequential action of two proteases, renin and angiotensin-converting enzyme. [6]
  • Ang II can be degraded to angiotensin III and IV, which appear to be active as well, by aminopeptidases. [3]
  • ANG II accelerates vpr(human immunodeficiency virus (HIV)-1 accessory genes)-induced podocyte injury in a mouse model of HIV-associated nephropathy. [7]

Classification

Hormone function

  • homeostasis
    • cardiovascular control
      • further hormone secretion

      Chemical classification

      • hormone
        • genome-encoded
          • renin-angiotensin system

        Composition

        Sequence
        DRVYIHPF

        Links to other resources

        UniProt P01019
        Ensembl ENST00000430091
        KEGG hsa:183
        • Anatomical structure: acidophil_mammotroph_cell_of_anterior_pituitary

          • Nonclassical Anterior Pituitary Substances:Peptides [8]
        • Anatomical structure: acidophil_somatotroph_cell_of_anterior_pituitary

        • Anatomical structure: basophil_gonadotroph_cell_of_anterior_pituitary_FSH

        • Anatomical structure: basophil_corticotroph_cell_of_anterior_pituitary

        • Anatomical structure: corpus_luteum

        • Anatomical structure: granulosa_cell

        • Anatomical structure: theca_cell

        • Anatomical structure: ovary

          • The luteal tissue is the major site of Ang II, ACE, AT1R, and VEGF. [9]

          Influenced by:

          • angiotensin II type 1 receptor
            in ovary
            • There is considerable evidence for a mammalian ovarian renin–angiotensin system, which may influence ovulation, angiogenesis and steroidogenesis via the autocrine and/or paracrine actions of the biologically active product of the cascade, angiotensin II. [10]
        • Anatomical structure: lipocyte_of_liver

          • HSCs incubated in the absence of angiotensinogen secreted moderate amounts of ANGII to the culture media. In contrast, incubation with angiotensinogen resulted in a dramatic increase in ANGII secretion. [11]

          Influenced by:

          • angiotensin II type 1 receptor
            in lipocyte_of_liver
        • Anatomical structure: fibroblast

          Influenced by:

          • angiotensin II type 1 receptor
            in fibroblast
            • In renal interstitial fibroblasts angiotensin II up-regulates angiotensinogen gene expression, thereby causing hyperplasia and extracellular matrix production via tha angiotensin type 1 receptor. [12]
        • Anatomical structure: proximal_tubule_of_nephron

          Influenced by:

          • angiotensin II type 1 receptor
            in proximal_tubule_of_nephron
            • Autocrine positive angiotensin II feedback: angiotensin II upregulates angiotensinogen mRNA expression, mediated via angiotensin type 1 receptor. [13]
        • Anatomical structure: kidney

          Influenced by:

          • angiotensin II type 1 receptor
            in proximal_tubule_of_nephron
            • Autocrine positive angiotensin II feedback: angiotensin II upregulates angiotensinogen mRNA expression, mediated via angiotensin type 1 receptor [13]
          • angiotensin II type 1 receptor
            in fibroblast
            • In renal interstitial fibroblasts angiotensin II up-regulates angiotensinogen gene expression, thereby causing hyperplasia and extracellular matrix production via tha angiotensin type 1 receptor. [12]
          • renin receptor
            in kidney
            • Renin binding to the renin receptor in the kidney secretes angiotensin 1 which is converted to angiotensin 2 [3]

        Targets

        Cellangiotensin II type 1 receptorangiotensin receptor 2angiotensin receptor 3
        adipose tissue Present
        Phenotypes
        • differentiation of preadipocytes
        • positive regulation of lipid metabolic process
        • regulation of lipid metabolic process
        Present
        Influences
        • NO
        adrenal cortex Present
        Phenotypes
        • positive regulation of renal sodium ion absorption
        adrenal gland Present
        Present
        blood vessel Present
        brain Present
        Phenotypes
        • regulation of blood pressure
        cardiac myocyte Present
        cell of adrenal gland zona glomerulosa Present
        Phenotypes
        • positive regulation of phospholipid catabolic process
        Influences
        • aldosterone
        circulatory system hematopoietic system Present
        Phenotypes
        • regulation of vasoconstriction
        • angiogenesis
        • vasoconstriction
        • regulation of vascular smooth muscle cell proliferation
        Present
        corpus luteum Present
        fibroblast Present
        Influences
        • angiotensin II
        • angiotensin II
        Goormaghtighs cell Present
        Influences
        • renin
        granulosa cell Present
        Phenotypes
        • regulation of angiogenesis
        heart Present
        Present
        Phenotypes
        • cell growth
        hepatocyte Present
        Influences
        • angiotensinogen
        Present
        kidney Present
        Phenotypes
        • salt and fluid balance
        • renal water reabsorption
        • blood pressure increase
        • negative regulation of natriuresis
        • regulation of blood pressure
        Present
        lipocyte of liver Present
        Influences
        • TGF-beta 1
        • angiotensin II
        Present
        Phenotypes
        • regulation of tissue remodeling
        lung Present
        ovary Present
        Phenotypes
        • steroidogenesis
        • angiogenesis
        • ovarian follicle development
        Influences
        • angiotensin II
        Present
        pancreas Present
        proximal tubule of nephron Present
        Influences
        • angiotensin II
        • angiotensin II
        Present
        tertiary follicle Present
        theca cell Present
        theca lutein cell Present
        uterus Present
        Reference