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Details for messenger / hormone: NT

EndoNet ID: ENH00099

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Synonyms

  • NT
  • neurotensin
  • NTS

General information

  • Prohormone convertases differentially process pro-neurotensin/neuromedin N in tissues and cell lines. [1]
  • Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation. [2]
  • Neurotensin is a tridecapteptide acting mostly in the brain and gastrointestinal tract. [3]
  • Stress-induced increases in NT signaling in pain modulatory regions may be responsible for the transition from pain facilitation to analgesia. [4]
  • Neurotensin stimulates interleukin-8 expression through modulation of I kappa B alpha phosphorylation and p65 transcriptional activity. [5]

Classification

Hormone function

  • CNS function
    • pain
    • immune response
      • activation

      Chemical classification

      • hormone
        • genome-encoded
          • peptide neurotransmitters
            • neurotensins

        Composition

        neurotensin, mature peptide

        Sequence 
        LYENKPRRP YIL

        neurotensin peptide

        Sequence 
        QLYENKPRR PYIL

        Links to other resources

        UniProt P30990
        Ensembl ENST00000256010
        KEGG hsa:4922

        • Anatomical structure: jejunum

          • Protein kinase D (PKD) family members (PKD1, 2, and 3) have been identified as important regulators of secretory transport at the trans-Golgi network: PKD1 contributes to stimulated NT secretion. [6]

        • Anatomical structure: brain

        • Anatomical structure: ileum

          • Protein kinase D (PKD) family members (PKD1, 2, and 3) have been identified as important regulators of secretory transport at the trans-Golgi network: PKD1 contributes to stimulated NT secretion. [6]

        • Anatomical structure: hypothalamus

        Targets

        Cellneurotensin receptor type 1NGF receptorNT-R2sortilin
        brain Present
        Phenotypes
        • eating behavior
        caudate nucleus Present
        central nerve system element Present
        Phenotypes
        • modulation of dopaminergic transmission
        • pituitary hormone release
        • eating behavior
        colon Present
        duodenum Present
        Phenotypes
        • lipid digestion
        neuron Present
        Phenotypes
        • migration of microglia
        nucleus accumbens Present
        		Present
        pancreas Present
        putamen Present
        stomach Present
        Phenotypes
        • decrease in gastric acid secretion
        Reference