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Details for messenger / hormone: calcitonin

EndoNet ID: ENH00103

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Synonyms

  • calcitonin
  • PDN-21
  • calcitonin carboxyl-terminal peptide
  • CALC1
  • MGC126648
  • CALCA
  • CT

General information

  • Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. [1]
  • Calcitonin inhibits osteoclast bone resorbing activity in part by down-regulating calpain activity. [2]
  • The calcitonin gene is alternatively expressed in a tissue-specific fashion producing either the calcium regulatory hormone CT in the thyroid or the neuropeptide calcitonin gene related peptide (CGRP) in the brain. [3]
  • Calcitonin is a thirty-two amino acid peptide that contains an N-terminal disulphide bridge and a C-terminal prolineamide residue. [4]

Classification

Hormone function

  • homeostasis
    • ion flow control

    Chemical classification

    • hormone
      • genome-encoded
        • calcitonin family

      Composition

      calcitonin

      Sequence 
      CGNLSTCML GTYTQDFNK FHTFPQTAI 
GVGAP
      UniProt P01258-1

      Links to other resources

      UniProt P01258
      Ensembl ENST00000396372
      KEGG hsa:796

      • Anatomical structure: parafollicular_cell

      • Anatomical structure: thyroid_gland

      Targets

      Cellcalcitonin receptorcalcitonin-receptor-like receptor
      alveolar macrophage Present
      area postrema of pons Present
      blood vessel Present
      cardiac myocyte Present
      cell of adrenal gland zona reticularis Present
      endocardium Present
      juxtaglomerular apparatus Present
      Leydig cell of testis Present
      lung Present
      mucosa of gastric wall Present
      nucleus accumbens Present
      osteoblast Present
      osteoclast Present
      Phenotypes
      • osteoporosis
      pancreatic islets Present
      Reference