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Details for messenger / hormone: IGF-1A

EndoNet ID: ENH00105

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Synonyms

  • Somatomedin-C
  • insulin-like growth factor IA
  • IGF-1A
  • somatomedin C
  • IGFIA
  • insulin-like growth factor 1 (somatomedin C)
  • mechano growth factor
  • MGF

General information

  • Alternative isoform of IGF-1.
  • Insulin suppresses and glucocorticoids enhance IGFBP-1 mRNA levels. (S. 1029) [1]
  • mRNA for IGFBP-1 is strongly expressed in decidua (although not in placental trophoblasts), liver and kidney.(S. 1029) [1]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • insulin family

      Composition

      Sequence
      MGKISSLPT QLFKCCFCD FLKVKMHTM 
      SSSHLFYLA LCLLTFTSS ATAGPETLC 
      GAELVDALQ FVCGDRGFY FNKPTGYGS 
      SSRRAPQTG IVDECCFRS CDLRRLEMY 
      CAPLKPAKS ARSVRAQRH TDMPKTQKE 
      VHLKNASRG SAGNKNYRM

      Links to other resources

      UniProt P01343-1
      Ensembl ENST00000337514
      KEGG hsa:3479
      • Anatomical structure: fat_cell

        • Expression is increased in obese state. [2]

      Targets

      CellIGF-1R
      acidophil somatotroph cell of anterior pituitary Present
      Phenotypes
      • cell growth
      • positive regulation of cell proliferation
      • negative regulation of apoptosis
      • transformation
      Influences
      • GH
      adrenal cortex Present
      chondrocyte Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      Influences
      • annexin A2
      lung Present
      Influences
      • amphiregulin
      microvascularendothelial cell Present
      osteoblast Present
      Reference