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Details for messenger / hormone: IGF-1B

EndoNet ID: ENH00106

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Synonyms

  • somatomedin C
  • Somatomedin-C
  • IGF-1B
  • insulin-like growth factor IB
  • IBP1
  • IGF1
  • mechano growth factor
  • MGF

General information

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • insulin family

      Composition

      Sequence
      GPETLCGAE LVDALQFVC GDRGFYFNK 
      PTGYGSSSR RAPQTGIVD ECCFRSCDL 
      RRLEMYCAP LKPAKSA

      Links to other resources

      UniProt P05019-1
      Ensembl ENST00000307046

        Targets

        CellIGF-1R
        acidophil somatotroph cell of anterior pituitary Present
        Phenotypes
        • cell growth
        • positive regulation of cell proliferation
        • negative regulation of apoptosis
        • transformation
        Influences
        • GH
        adrenal cortex Present
        chondrocyte Present
        continuous vascular endothelial cell of blood vessels and lymphatics Present
        continuous vascular endothelial cell of blood vessels and lymphatics Present
        Influences
        • annexin A2
        lung Present
        Influences
        • amphiregulin
        microvascularendothelial cell Present
        osteoblast Present
        Reference