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Details for messenger / hormone: inhibin B

EndoNet ID: ENH00120

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Synonyms

  • inhibin B
  • inhibin alpha and beta B
  • activin AB beta
  • inhibin, beta-2

General information

  • Inhibits the secretion of follitropin by the pituitary gland.
  • Heterodimer of inhibin alpha and beta B subunit.

Classification

Hormone function

  • homeostasis
    • further hormone secretion

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TGF-beta family

      Composition

      inhibin beta B (1 times)

      Sequence
      GLECDGRTN LCCRQQFFI DFRLIGWND 
      WIIAPTGYY GNYCEGSCP AYLAGVPGS 
      ASSFHTAVV NQYRMRGLN PGTVNSCCI 
      PTKLSTMSM LYFDDEYNI VKRDVPNMI 
      VEECGCA
      UniProt P09529

      inhibin alpha (1 times)

      Sequence
      STPLMSWPW SPSALRLLQ RPPEEPAAH 
      ANCHRVALN ISFQELGWE RWIVYPPSF 
      IFHYCHGGC GLHIPPNLS LPVPGAPPT 
      PAQPYSLLP GAQPCCAAL PGTMRPLHV 
      RTTSDGGYS FKYETVPNL LTQHCACI
      UniProt P05111

      Links to other resources

      • Anatomical structure: Sertoli_cell

        • Support for the developing spermatogenic cells and form a blood-testis barrier to large molekular weight compounds.

        Influenced by:

        • follitropin receptor
          in Sertoli_cell
      • Anatomical structure: granulosa_cell

        • Inhibin B is a product of the granulosa cells of growing preantral and antral follicles. [1]
      • Anatomical structure: ovarian_follicle_cell

      • Anatomical structure: corpus_luteum

      Targets

      CellACTRIIA
      basophil gonadotroph cell of anterior pituitary FSH Present
      Influences
      • FSH
      • LH
      cell of endometrium of uterus Present
      Phenotypes
      • cell differentiation
      Reference