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Details for messenger / hormone: TSH

EndoNet ID: ENH00121

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Synonyms

  • TSH
  • thyroidea-stimulating-hormone
  • thyrotrophin
  • thyrotropin
  • thyrotropic hormone

General information

  • Serum TSH levels can change the myocardial velocities detected by PWTD (pulsed wave tissue Doppler). [1]
  • Comsposed of alpha (=CGA) and beta subunit (=TSHB). [2]

Classification

Hormone function

  • homeostasis
    • ion flow control
      • further hormone secretion

      Chemical classification

      • hormone
        • genome-encoded
          • glycoprotein hormones family

      Composition

      alpha (1 times)

      Sequence 
      APDVQDCPE CTLQENPFF SQPGAPILQ 
CMGCCFSRA YPTPLRSKK TMLVQKNVT 
SESTCCVAK SYNRVTVMG GFKVENHTA 
CHCSTCYYH KS
      UniProt P01215

      beta (1 times)

      Sequence 
      FCIPTEYTM HIERRECAY CLTINTTIC 
AGYCMTRDI NGKLFLPKY ALSQDVCTY 
RDFIYRTVE IPGCPLHVA PYFSYPVAL 
SCKCGKCNT DYSDCIHEA IKTNYCTKP 
QKSY
      UniProt P01222

      Links to other resources

      • Anatomical structure: basophil_thyrotroph_cell_of_anterior_pituitary

        • SSTR2 and SSTR5 mediate suppression of GH and TSH secretion. [2]

        Influenced by:

        • sst2
          in basophil_thyrotroph_cell_of_anterior_pituitary
        • sst5
          in basophil_thyrotroph_cell_of_anterior_pituitary
        • TRH-R
          in basophil_thyrotroph_cell_of_anterior_pituitary
        • RAR
          in basophil_thyrotroph_cell_of_anterior_pituitary
          • Retinoic acid plays an important inhibitory role on in vivo secretion of TSH and this effect is unrelated to the thyroid status of the animals. [3]
        • neuromedin B receptor
          in basophil_thyrotroph_cell_of_anterior_pituitary
          • Neuromedin B acts as a constitutive autocrine TSH-release inhibitor. [4]

      Targets

      Cellthyroid stimulating hormone receptor
      basophil thyrotroph cell of anterior pituitary Present
      chondroblast Present
      chondroclast Present
      thyroid gland Present
      Phenotypes
      • Graves-Basedow disease
      • Hashimoto thyroiditis
      Influences
      • ↑ T4
      • ↑ T3
      Reference