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Details for messenger / hormone: TRH

EndoNet ID: ENH00122

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Synonyms

  • TRH
  • thyrotropin-releasing-hormone
  • thyroliberin
  • Protirelin
  • TSH-releasing factor
  • thyrotropin-releasing factor
  • thyrotropin-releasing hormone
  • Prothyroliberin

General information

  • Tripeptide pyro-Glu-His-Pro-amide [1]
  • TRH stimulation testing in subfertile patients is not helpful to identify patients with subclinical hypothyroidism. [2]
  • TRH therapy is successful for the associated cerebellar dysfunction and brainstem-related symptoms. [3]

Classification

Hormone function

  • homeostasis
    • further hormone secretion

    Chemical classification

    • hormone
      • genome-encoded
        • TRH family

      Composition

      Prothyroliberin

      • Contains 6 copies of the sequence -Glu-His-Pro-Gly-, flanked by di-basic peptides that are later cleaved to give the mature TRH molecule.
      Sequence
      QPEAAQQEA VTAAEHPGL DDFLRQVER 
      LLFLRENIQ RLQGDQGEH SASQIFQSD 
      WLSKRQHPG KREEEEEEG VEEEEEEEG 
      GAVGPHKRQ HPGRREDEA SWSVDVTQH 
      KRQHPGRRS PWLAYAVPK RQHPGRRLA 
      DPKAQRSWE EEEEEEERE EDLMPEKRQ 
      HPGKRALGG PCGPQGAYG QAGLLLGLL 
      DDLSRSQGA EEKRQHPGR RAAWVREPL 
      EE

      Links to other resources

      UniProt P20396
      Ensembl ENST00000302649
      KEGG hsa:7200
      • Anatomical structure: periventricular_nucleus_of_hypothalamus

        • CART neurons in the posterior periventricular nucleus (Pe) coexpress thyrotropin-releasing hormone (TRH) mRNA. [4]
      • Anatomical structure: paraventricular_nucleus_of_hypothalamus

        • S.101 [5]
        • Many TRH-containing neurons were present in the paraventricular nucleus (PVN), especially in the dorsocaudal part of this nucleus. [6]

        Influenced by:

        • THRB1
          in paraventricular_nucleus_of_hypothalamus
        • THRA1
          in paraventricular_nucleus_of_hypothalamus
        • thyroid hormone receptor beta 2
          in paraventricular_nucleus_of_hypothalamus
        • leptin receptor
          in paraventricular_nucleus_of_hypothalamus
          • Leptin stimulates TRH mRNA production and releases TRH but only from hypothalamic neurons of the PVN. S.138 [7]
      • Anatomical structure: acidophil_mammotroph_cell_of_anterior_pituitary

        • Nonclassical Anterior Pituitary Substances: Peptides [8]
      • Anatomical structure: acidophil_somatotroph_cell_of_anterior_pituitary

      • Anatomical structure: basophil_gonadotroph_cell_of_anterior_pituitary_FSH

      • Anatomical structure: cerebrospinal_fluid

      • Anatomical structure: lung

      • Anatomical structure: placenta

      • Anatomical structure: basophil_thyrotroph_cell_of_anterior_pituitary

        Influenced by:

        • TRH-R
          in basophil_thyrotroph_cell_of_anterior_pituitary
          • Stimulates thyroid-stimulating hormone (TSH) release from anterior pituitary [9]

      Targets

      CellTRH-R
      acidophil mammotroph cell of anterior pituitary Present
      Influences
      • PRL
      basophil thyrotroph cell of anterior pituitary Present
      Phenotypes
      • Hypothyroidism
      Influences
      • TSH
      • TRH
      • neuromedin B
      cell of intermediate pituitary Present
      Influences
      • MSH
      pituitary gland of diencephalon Present
      Influences
      • GH
      Reference