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Details for messenger / hormone: somatostatin

EndoNet ID: ENH00124

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Synonyms

  • growth hormone release-inhibiting factor
  • SST
  • SRIF
  • somatostatin
  • SIH
  • GHRIH
  • SRIH
  • somatotropin release-inhibiting factor

General information

  • There are two endogenous bioactive forms of SST, i.e., SST-14 and SST-28, that act on a diverse array of endocrine, exocrine, neuronal, and immune cell targets to inhibit secretion, modulate neurotransmission, and regulate cell division. [1]
  • SST inhibits insulin and glucagon secretion, consistent with a role for SST in regulating alpha- and beta-cell function. [2]

Classification

Hormone function

  • homeostasis
    • further hormone secretion

    Chemical classification

    • hormone
      • genome-encoded
        • somatostatin family

      Links to other resources

      UniProt P61278
      Ensembl ENST00000287641
      KEGG hsa:6750
      • Anatomical structure: D_cell_of_gastrointestinal_tract

        Influenced by:

        • CCK-2
          in D_cell_of_gastrointestinal_tract
          • CCK and gastrin stimulate somatostatin secretion. [3]
      • Anatomical structure: paraventricular_nucleus_of_hypothalamus

      • Anatomical structure: digestive_system

        Influenced by:

        • CCK-2
          in digestive_system
      • Anatomical structure: D_cell

        • SST also inhibits pancreatic polypeptide as well as endogenous SST secretion from delta-cells through an autofeedback mechanism. [1]

        Influenced by:

        • sst2
          in D_cell
        • sst3
          in D_cell
        • sst1
          in D_cell
        • sst5
          in D_cell
        • CCK-1
          in D_cell
          • The CCK1 receptor mRNA and protein have been localized in the human gastric mucosa within D cells, where CCK can stimulate somatostatin secretion. [4]

      Targets

      Cellsst1sst2sst3sst4sst5
      acidophil somatotroph cell of anterior pituitary Present
      Influences
      • GH
      Present
      Influences
      • GH
      alpha cell of islet of Langerhans Present
      Present
      Influences
      • glucagon
      Present
      Influences
      • glucagon
      Present
      Influences
      • glucagon
      arcuate nucleus of hypothalamus Present
      basophil thyrotroph cell of anterior pituitary Present
      Influences
      • TSH
      Present
      Influences
      • TSH
      beta cell of islet of Langerhans Present
      Influences
      • insulin
      Present
      Influences
      • insulin
      Present
      Influences
      • insulin
      Present
      Influences
      • insulin
      Present
      Influences
      • insulin
      brain Present
      Present
      Present
      Present
      Present
      D cell Present
      Influences
      • somatostatin
      Present
      Influences
      • somatostatin
      Present
      Influences
      • somatostatin
      Present
      Influences
      • somatostatin
      hippocampus Present
      kidney Present
      Present
      lung Present
      pituitary gland of diencephalon Present
      Present
      Influences
      • ACTH
      Present
      Present
      Influences
      • PRL
      • ACTH
      placenta Present
      stomach Present
      Present
      Present
      Present
      Present
      zymogenic cell of gastric gland Present
      Phenotypes
      • inhibition of pepsinogen release
      Reference