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Details for messenger / hormone: GIP

EndoNet ID: ENH00126

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Synonyms

  • gastric inhibitory polypeptide
  • glucose-dependent insulinotropic polypeptide
  • GIP

General information

  • Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. [1]

Classification

Hormone function

  • homeostasis
    • ion flow control
      • further hormone secretion

      Chemical classification

      • hormone
        • genome-encoded
          • gastrointestinal hormones
            • incretins

        Composition

        gastric inhibitory polypeptide

        Sequence
        YAEGTFISD YSIAMDKIH QQDFVNWLL 
        AQKGKKNDW KHNITQ

        Links to other resources

        UniProt P09681
        Ensembl ENST00000357424
        KEGG hsa:2695
        • Anatomical structure: duodenum

          • Positive GIP cells contained large round, or sometimes irregular, electron-dense, secretory granules, many of these possessed the characteristic dense centralcores, surrounded by a lighter matrix. On the basis of the characteristic appearance of the granules, the cells were identified as K cells. [2]
        • Anatomical structure: jejunum

          • Positive GIP cells contained large round, or sometimes irregular, electron-dense, secretory granules, many of these possessed the characteristic dense centralcores, surrounded by a lighter matrix. On the basis of the characteristic appearance of the granules, the cells were identified as K cells. [2]
        • Anatomical structure: alpha_cell_of_islet_of_Langerhans

        Targets

        Cellgastric inhibitory polypeptide receptor
        beta cell of islet of Langerhans Present
        Influences
        • insulin
        Reference