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Details for messenger / hormone: pancreatic polypeptide

EndoNet ID: ENH00128

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Synonyms

  • pancreatic prohormone
  • pancreatic polypeptide
  • PP

General information

  • PP is primarily expressed in the endocrine cells of the pancreas. [1]
  • Ghrelin, motilin, and secretin stimulates PP release, whereas somatostatin and its analogs significantly reduce plasma PP concentrations. [1]
  • Released in response to food intake. [1]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • peptide neurotransmitters
          • NPY family

      Composition

      pancreatic hormone

      Sequence
      APLEPVYPG DNATPEQMA QYAADLRRY 
      INMLTRPRY

      Links to other resources

      UniProt P01298
      Ensembl ENST00000225992
      KEGG hsa:5539
      • Anatomical structure: pp_cell

      • Anatomical structure: alpha_cell_of_islet_of_Langerhans

      Targets

      CellNPY1-RNPY4-R
      arcuate nucleus of hypothalamus Present
      Phenotypes
      • positive regulation of appetite
      Present
      Phenotypes
      • positive regulation of appetite
      colon Present
      ileum Present
      kidney Present
      left coronary artery Present
      osteoblast Present
      pancreas Present
      right coronary artery Present
      small intestine Present
      Reference