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Details for messenger / hormone: GnRH-I

EndoNet ID: ENH00134

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Synonyms

  • GnRH-I
  • LH-RH I
  • luteinizing hormone-releasing hormone I
  • FRS
  • folliliberin
  • luliberin 1
  • LHRH
  • follicle-stimulating hormone-releasing factor
  • gonadoliberin I
  • luberin
  • gonadotropin releasing hormone
  • GNRH1
  • follicle-stimulating hormone-releasing hormone
  • Progonadoliberin-1
  • GnRH-associated peptide I
  • Gonadorelin
  • luliberin I
  • gonadotropin-releasing hormone I
  • progonadoliberin I

General information

  • Is present in the hypothalamus and acts at the pituitary. [1]
  • Functions as a neurohormone, regulating the pituitary in mediating the release of gonadotropin. [1]
  • A decapeptide secreted by the hypothalamus in a pulsative manner, causing the anterior pituitary to release LH and FSM. [2]

Classification

Hormone function

  • homeostasis
    • further hormone secretion
    • reproduction and sexual differentiation
      • reproduction

      Chemical classification

      • hormone
        • genome-encoded
          • GnRH family

        Composition

        GnRH-associated peptide 1

        Sequence
        DAENLIDSF QEIVKEVGQ LAETQRFEC 
        TTHQPRSPL RDLKGALES LIEEETGQK 
        KI

        Gonadoliberin-1

        • Progonadoliberin-1 is cleaved into Gonadoliberin-1 and GnRH-associated peptide 1.
        Sequence
        QHWSYGLRP G

        Links to other resources

        UniProt P01148
        Ensembl ENST00000421054
        KEGG 2796
        • Anatomical structure: arcuate_nucleus_of_hypothalamus

          • Estrogen directly respresses GnRH. [3]

          Influenced by:

          • ER-beta
            in arcuate_nucleus_of_hypothalamus
          • unspecified testosterone receptor 1
            in arcuate_nucleus_of_hypothalamus
          • progesterone receptor A
            in arcuate_nucleus_of_hypothalamus
          • NPY5-R
            in arcuate_nucleus_of_hypothalamus
          • leptin receptor
            in arcuate_nucleus_of_hypothalamus
            • Decrease in Leptin causes inhibition of GnRH/LH secretion in rats during lactation [4]
        • Anatomical structure: gonadotropin_releasing_hormone_neuron

          Influenced by:

          • GPR54
            in gonadotropin_releasing_hormone_neuron
            • Kisspeptins stimulate the secretion of gonadotropins from the pituitary by stimulating the release of GnRH from the forebrain after the activation of GPR54, which is expressed by GnRH neurons. [5]
          • melatonin 1 receptor
            in hypothalamus
            • Potential signal transduction mechanisms involved in the control of GnRH gene expression and secretion by melatonin. [6]
          • NPFF-R1
            in hypothalamus
            • Thus, GnIH/RFRP may also inhibit gonadotropin synthesis and release by inhibiting GnRH neurons [7]
        • Anatomical structure: hypothalamus

          Influenced by:

          • progesterone receptor
            in hypothalamus
            • ovairan progesterione is essential for the secretion of GnRH, mediated by interaction with cognate intracellular progesterone receptor. [8]
        • Anatomical structure: pituitary_gland_of_diencephalon

        Targets

        Cellgonadotropin-releasing hormone receptorgonadotropin-releasing hormone receptor 2
        basophil gonadotroph cell of anterior pituitary FSH Present
        Phenotypes
        • hypogonadotropic hypogonadism
        Influences
        • LH
        • FSH
        • secretoneurin
        • secretogranin-2
        • FSH
        • chromogranin A
        Reference