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Details for messenger / hormone: ADM

EndoNet ID: ENH00137

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Synonyms

  • ProAM N-terminal 20 peptide
  • ADM
  • adrenomedullin
  • AM

General information

  • AM is elevated in plasma from patients with pancreatic dysfunctions such as type 1 or type 2 diabetes and insulinoma. [1]
  • ADM has been demonstrated to protect endothelial cells against apoptotic cell death, an effect which is probably mediated by NO, and to play a role in the process of angiogenesis. [2]
  • Adrenomedullin (ADM) is a potent stimulator of osteoblastic activity and promotes bone growth in vivo. [3]
  • Adrenomedullin is a 52-amino-acid peptide that also has potent vasodilatory effects. It is synthesized by non-neuronal cells such as endothelial cells, vascular smooth muscle cells, a number of tumor cells as well as monocytes and macrophages. [2]

Classification

Hormone function

  • CNS function
    • neurotransmitter
    • homeostasis
      • pulmonary control
        • cardiovascular control
        • development and growth
          • growth inhibition

          Chemical classification

          • hormone
            • genome-encoded

          Composition

          Sequence 
          YRQSMNNFQ GLRSFGCRF GTCTVQKLA 
HQIYQFTDK DKDNVAPRS KISPQGY

          Links to other resources

          UniProt P35318
          Ensembl ENST00000278175
          KEGG hsa:133

          • Anatomical structure: macrophage

          • Anatomical structure: monocyte

          • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

            • Adrenomedullin is synthesized and secreted in abundance by endothelial cells. [2]

          • Anatomical structure: cardiac_myocyte

            • The expression of ADM by cardiac myocytes has been described in a number of species including man and was shown to be increased in cardiac failure and ischemic heart disease (Jougasaki et al. 1997, 2001). . [2]

          • Anatomical structure: adrenal_medulla

          Targets

          Celladrenomedullin receptorcalcitonin-receptor-like receptorGRP-R
          adrenal cortex Present
          alveolar macrophage Present
          amygdaloid body Present
          astrocyte Present
          beta cell of islet of Langerhans Present
          Influences
          • ↓ insulin
          blood vessel Present
          caecum Present
          cardiac myocyte Present
          cell of adrenal gland zona reticularis Present
          colon Present
          Phenotypes
          • regulation of epithelial cell proliferation
          duodenum Present
          endocardium Present
          ileum Present
          Phenotypes
          • gatrointestinal motility
          juxtaglomerular apparatus Present
          Leydig cell of testis Present
          lung Present
          mucosa of gastric wall Present
          oesophagus Present
          osteoblast Present
          pancreas Present
          Phenotypes
          • positive regulation of pancreatic juice secretion
          • regulation of epithelial cell proliferation
          pancreatic islets Present
          rectum Present
          stomach Present
          Influences
          • ↑ GRP
          Reference