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Details for messenger / hormone: IAPP

EndoNet ID: ENH00140

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Synonyms

  • IAPP
  • amylin
  • islet amyloid polypeptide
  • DAP
  • insulinoma amyloid peptide
  • diabetes-associated peptide

General information

  • The area postrema (AP) plays a predominant role in peripheral amylin's satiating effect. [1]
  • Amylin reduces food intake, gastric acid secretion, limits the rate of gastric emptying and diminishes pancreatic glucagon and digestive enzyme secretion. [1]
  • Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. [2]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • calcitonin family

      Composition

      Sequence
      KCNTATCAT QRLANFLVH SSNNFGAIL 
      SSTNVGSNT Y

      Links to other resources

      UniProt P10997
      Ensembl ENST00000240652
      KEGG hsa:3375
      • Anatomical structure: osteoblast

      • Anatomical structure: beta_cell_of_islet_of_Langerhans

        • Amylin is colocated with insulin in the pancreatic beta cells and is cosecreted with insulin from the pancreatic beta cells in a constant molar ratio. The ratio of insulin to amylin is approximately 20 to 1. [3]
        • In persons without diabetes amylin is rapidly increased after meal. In type 1 diabetes, amylin, like insulin, is virtually absent. In insulin-treated type 2 diabetes amylin and insulin are still produced but in amounts insufficient to maintain normal glucose levels. [3]

      Targets

      Cellcalcitonin receptor
      area postrema of pons Present
      nucleus accumbens Present
      osteoclast Present
      Phenotypes
      • osteoporosis
      Reference