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Details for messenger / hormone: GH-2

EndoNet ID: ENH00147

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Synonyms

  • GH-2
  • placenta-specific growth hormone
  • growth hormone 2
  • GH2
  • growth hormone variant
  • GHV

General information

  • Stimulates the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. [1]
  • Can form a complex either with GHBP or with the alpha2-macroglobulin complex. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • growth hormones

      Composition

      GH-V1

      Sequence
      FPTIPLSRL FDNAMLRAR RLYQLAYDT 
      YQEFEEAYI LKEQKYSFL QNPQTSLCF 
      SESIPTPSN RVKTQQKSN LELLRISLL 
      LIQSWLEPV QLLRSVFAN SLVYGASDS 
      NVYRHLKDL EEGIQTLMW RLEDGSPRT 
      GQIFNQSYS KFDTKSHND DALLKNYGL 
      LYCFRKDMD KVETFLRIV QCRSVEGSC 
      GF
      UniProt P01242-1

      Links to other resources

      UniProt P01242
      Ensembl ENST00000423893
      KEGG hsa:2689

        Targets

        Cellgrowth hormone receptor
        chondrocyte Present
        fat cell Present
        Influences
        • leptin
        hepatocyte Present
        pituitary gland of diencephalon Present
        Phenotypes
        • dwarfism
        • Acromegaly due to pituitary adenoma
        skeleton muscle Present
        Phenotypes
        • Laron syndrome
        thymic epithelial cell Present
        Influences
        • Thymulin
        Reference