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Details for messenger / hormone: GPH

EndoNet ID: ENH00148

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Synonyms

  • GPH
  • glycoprotein hormone
  • GPH alpha2/beta5
  • GPHA2/GPHB5

General information

  • Stimulates the thyroid. Binds and activates THSR. [1]
  • Heterodimer of GHPA2 (alpha2) and GPHB5 (beta5).

Classification

Hormone function

  • homeostasis
    • further hormone secretion

    Chemical classification

    • hormone
      • genome-encoded
        • glycoprotein hormones family

    Composition

    alpha2 (1 times)

    Sequence 
    QEAVIPGCH LHPFNVTVR SDRQGTCQG 
SHVAQACVG HCESSAFPS RYSVLVASG 
YRHNITSVS QCCTISGLK KVKVQLQCV 
GSRREELEI FTARACQCD MCRLSRY
    UniProt Q96T91

    beta5 (1 times)

    Sequence 
    ASSGNLRTF VGCAVREFT FLAKKPGCR 
GFGSPRMPA GVAVRPGRN PFWNPPILK 
PIIESVPTT RPNR
    UniProt Q86YW7

    Links to other resources

      Targets

      Cellthyroid stimulating hormone receptor
      basophil thyrotroph cell of anterior pituitary Present
      chondroblast Present
      chondroclast Present
      thyroid gland Present
      Phenotypes
      • Graves-Basedow disease
      • Hashimoto thyroiditis
      Influences
      • ↑ T4
      • ↑ T3
      Reference