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Details for messenger / hormone: MCH

EndoNet ID: ENH00157

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  • Pro-MCH
  • MCH
  • melanin-concentrating hormone
  • PMCH
  • pro-melanin-concentrating hormone

General information

  • Several lines of investigation suggest that the hypothalamic neuropeptide melanin-concentrating hormone (MCH) regulates body weight in mammals. [1]
  • MCH participates in the hypothalamic regulation of body weight. [2]
  • Melanin-concentrating hormone (MCH) is involved in the regulation of feeding and energy homeostasis. [3]


Hormone function

  • metabolism
    • nutrient supply

    Chemical classification



    Links to other resources

    UniProt P20382
    Ensembl ENST00000329406
    KEGG hsa:5367
    • Anatomical structure: lateral_hypothalamic_area

      • MCH is exclusively produced in neurons of the lateral hypothalamic area that give off fibers to the widespread brain regions. [4]
    • Anatomical structure: periventricular_nucleus_of_hypothalamus

      • In the human hypothalamus, neuronal cell bodies stained for MCH were observed only in the periventricular area. [5]
    • Anatomical structure: brain

    • Anatomical structure: cerebellum

    • Anatomical structure: duodenum

    • Anatomical structure: skin

    • Anatomical structure: testis

    • Anatomical structure: thymus

    • Anatomical structure: tonsil

    • Anatomical structure: blood

    • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    • Anatomical structure: spermatocyte