Status
Please wait ...

Details for messenger / hormone: orexin-A

EndoNet ID: ENH00158

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be:

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • Hypocretin-2
  • Hypocretin
  • Orexin
  • orexin-A
  • hypocretin-1
  • Hcrt1

General information

  • Orexins, after the Greek word "orexis," which means appetite, have a physiological role in the stimulation of food intake. [1]

Classification

Hormone function

  • CNS function
    • circadian rhythm / sleep
    • metabolism
      • nutrient supply

      Chemical classification

      Composition

      precursor orexin

      Sequence
      MNLPSTKVS WAAVTLLLL LLLLPPALL 
      SSGAAAQPL PDCCRQKTC SCRLYELLH 
      GAGNHAAGI LTLGKRRSG PPGLQGRLQ 
      RLLQASGNH AAGILTMGR RAGAEPAPR 
      PCLGRRCSA PAAASVAPG GQSGI

      orexin-A

      Sequence
      QPLPDCCRQ KTCSCRLYE LLHGAGNHA 
      AGILTL

      Links to other resources

      UniProt O43612
      Ensembl ENST00000293330
      KEGG hsa:3060
      • Anatomical structure: lateral_hypothalamic_area

        Influenced by:

        • leptin receptor isoform b
          in hypothalamus
          • Leptin inhibits the secretion of orexin [2]
        • orexin receptor 1
          in lateral_hypothalamic_area
        • GHS-R1a
          in hypothalamus
          • Ghrelin stimulates the secretion of orexin [2]
        • glucocorticoid receptor
          in hypothalamus
          • Glucose inhibits the orexin neurons in the hypothalamus
      • Anatomical structure: hypothalamus

      Targets

      Cellorexin receptor 1orexin receptor 2
      acidophil somatotroph cell of anterior pituitary Present
      basophil corticotroph cell of anterior pituitary Present
      lateral hypothalamic area Present
      Phenotypes
      • regulation of feeding behavior
      Influences
      • orexin-B
      • orexin-A
      Reference