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Details for messenger / hormone: angiotensin I

EndoNet ID: ENH00171

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Synonyms

  • Des-Asp[1]-angiotensin II
  • angiotensin III
  • angiotensin II
  • serpin A8
  • Angiotensinogen
  • angiotensin I
  • ang I
  • angiotensin 1

General information

  • In the classical RAS, circulating renal-derived renin cleaves angiotensinogen, a protein principally synthesized in the liver, to form the decapeptide angiotensin I (Ang I), an inactive substance. Subsequently, conversion of Ang I to Ang II occurs rapidly by the action of the dipeptidyl carboxypeptidase angiotensin-converting enzyme (ACE) in the lungs. [1]

Classification

Hormone function

  • homeostasis
    • hormone precursor

    Chemical classification

    • hormone
      • genome-encoded
        • renin-angiotensin system

      Composition

      Sequence 
      DRVYIHPFH L

      Links to other resources

      UniProt P01019
      Ensembl ENST00000366667
      KEGG hsa:183

        Targets

        Cell
        No records found.
        Reference