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Details for messenger / hormone: cholecystokinin 39

EndoNet ID: ENH00175

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Synonyms

  • (1-49)-CCK58
  • Cholecystokinin
  • cholecystokinin 39
  • CCK39

General information

Classification

Hormone function

  • homeostasis
    • further hormone secretion

    Chemical classification

    • hormone
      • genome-encoded
        • gastrointestinal hormones

    Composition

    Sequence
    YIQQARKAP SGRMSIVKN LQNLDPSHR 
    ISDRDYMGW MDF

    Links to other resources

    UniProt P06307
    Ensembl ENST00000434608
    KEGG hsa:885
    • Anatomical structure: small_intestine

      • It is well recognized that mammals synthesize CCK peptides in the I-cells of the small intestine, as well as the central nervous system [1]
    • Anatomical structure: central_nerve_system_element

    Targets

    CellCCK-1CCK-2
    alpha cell of islet of Langerhans Present
    Influences
    • glucagon
    cell of adrenal gland zona glomerulosa Present
    Influences
    • aldosterone
    Present
    Influences
    • aldosterone
    colon Present
    Phenotypes
    • induction of smooth muscle contraction
    Present
    Phenotypes
    • induction of smooth muscle contraction
    D cell Present
    Influences
    • somatostatin
    D cell of gastrointestinal tract Present
    Influences
    • somatostatin
    • gastrin
    digestive system Present
    Influences
    • somatostatin
    enterochromaffin like cell Present
    Phenotypes
    • positive regulation of smooth muscle proliferation
    Influences
    • histamine
    gallbladder Present
    Phenotypes
    • gastro-intestinal system smooth muscle contraction
    hypothalamus Present
    Phenotypes
    • negative regulation of appetite
    Present
    Phenotypes
    • negative regulation of appetite
    intestinal smooth muscle cell Present
    Phenotypes
    • induction of smooth muscle contraction
    Present
    Phenotypes
    • induction of smooth muscle contraction
    mucosa of small intestine Present
    Present
    neuron Present
    oxyntic cell of gastric gland Present
    Present
    Phenotypes
    • positive regulation of gastric acid secretion
    pancreas Present
    Phenotypes
    • mitogen activity
    • positive regulation of pancreatic juice secretion
    Influences
    • pancreatic alpha-amylase
    smooth muscle Present
    stomach Present
    Phenotypes
    • inhibition of gastric emptying
    zymogenic cell of gastric gland Present
    Reference