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Details for messenger / hormone: LIF

EndoNet ID: ENH00185

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Synonyms

  • LIF
  • cholinergic differentiation factor
  • leukaemia inhibitory factor
  • differentiation-stimulating factor
  • D factor
  • melanoma-derived LPL inhibitor
  • MLPLI
  • emfilermin
  • leukemia-inhibitory factor
  • human interleukin in DA cells
  • HILDA
  • leukemia inhibitory factor

General information

  • LIF acts in cell proliferation (in myoblasts and megakaryocytes), the induction (in M1 cells) or suppression (in embryonic stem cells) of differentiation, and the induction of mature cell function (in neurons, adipocytes, and hepatocytes). [1]
  • IL-6-type cytokine, stimulate type-2 acute phase proteins, such as fibrinogen, alpha-1-antitrypsin, haptoglobin and ceruloplasmin. [2]
  • Enhance glucocorticoid production. [3]
  • Belongs to the interleukin-6 subfamily. [4]
  • Leukaemia inhibitory factor (LIF) is a cytokine that induces macrophage differentiation of the murine M1 myeloid leukaemia cell line. [5]
  • The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are an important family of mediators involved in the regulation of the acute-phase response to injury and infection. [6]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • IL-6-type cytokines

      Composition

      • According to NCBI (Accession number AAA51699), this sequence might have additional "VLHWKHG AG"-part at the N-terminal.
      Sequence 
      SPLPITPVN ATCAIRHPC HNNLMNQIR 
SQLAQLNGS ANALFILYY TAQGEPFPN 
NLDKLCGPN VTDFPPFHA NGTEKAKLV 
ELYRIVVYL GTSLGNITR DQKILNPSA 
LSLHSKLNA TADILRGLL SNVLCRLCS 
KYHVGHVDV TYGPDTSGK DVFQKKKLG 
CQLLGKYKQ IIAVLAQAF
      UniProt P15018

      Links to other resources

      UniProt P15018
      Ensembl ENST00000249075
      KEGG hsa:3976

      • Anatomical structure: thymus

        • Human thymic epithelial cells produce numerous cytokines including IL1, IL6, TGF alpha, leukemia inhibitory factor (LIF), M-CSF, G-CSF and GM-CSF- molecules that likely play important roles in multiple stages of thymocyte selection, activation and differentiation. [7]

      • Anatomical structure: cell_of_endometrium_of_uterus

        • LIF is produced in high amounts by the human endometrium and the trophoblast itself, and LIF receptors are present on cytotrophoblast cells. [8]

        Influenced by:

        • TGF-beta type II receptor
          in cell_of_endometrium_of_uterus
          • TGF-beta1 (from 10<sup>–12</sup> to 10<sup>–8</sup>M ), -beta 2 , -beta 3 and activin A (10<sup>–10 and 10</sup>–8 M ) increases LIF secretion by human endometrial epithelium cultures. [9]
        • IL-1RI
          in cell_of_endometrium_of_uterus
          • Treatment with IL-1beta (10 <sup>–9</sup> M ) strongly stimulated LIF and IL-6 production. [9]

      • Anatomical structure: kidney

        • The ureteric bud expressed LIF, and metanephric mesenchyme expressed its receptors. [10]

      • Anatomical structure: adipose_tissue

      • Anatomical structure: osteoblast

      Targets

      Reference