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Details for messenger / hormone: IGFBP-2

EndoNet ID: ENH00191

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Synonyms

  • IGFBP-2
  • insulin-like growth factor binding protein 2
  • IBP-2
  • IGF-binding protein 2

General information

  • IGFBP-2 binds IGF-1. IGFBPs regulate IGF bioavailability in the pericellular space. [1]

Classification

Hormone function

  • development and growth
    • environment adaptation

    Chemical classification

    • hormone
      • genome-encoded
        • IGFBP family

      Composition

      IGFBP-2

      • The IGFBP-2 gene is located on the long arm of chromosome 2. [2]
      Sequence 
      EVLFRCPPC TPERLAACG PPPVAPPAA 
VAAVAGGAR MPCAELVRE PGCGCCSVC 
ARLEGEACG VYTPRCGQG LRCYPHPGS 
ELPLQALVM GEGTCEKRR DAEYGASPE 
QVADNGDDH SEGGLVENH VDSTMNMLG 
GGGSAGRKP LKSGMKELA VFREKVTEQ 
HRQMGKGGK HHLGLEEPK KLRPPPART 
PCQQELDQV LERISTMRL PDERGPLEH 
LYSLHIPNC DKHGLYNLK QCKMSLNGQ 
RGECWCVNP NTGKLIQGA PTIRGDPEC 
HLFYNEQQE ARGVHTQRM Q
      UniProt P18065

      Links to other resources

      UniProt P18065
      Ensembl ENSG00000115457
      KEGG hsa:3485

      • Anatomical structure: lipocyte_of_liver

        • HSCs express IGFBP-2 through IGFBP-6 mRNAs. [3]

      • Anatomical structure: hepatocyte

      • Anatomical structure: osteoblast

        Influenced by:

        • AR
          in osteoblast
          • 5-alpha-DHT increased IGFBP-2 and -3 mRNA and protein levels by 6- and 7-fold (for mRNA) and 3- and 5-fold (for protein). [4]

      Targets

      Cell
      No records found.
      Reference