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Details for messenger / hormone: IGFBP-3

EndoNet ID: ENH00192

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Synonyms

  • IGFBP-3
  • insulin-like growth factor binding protein 3
  • IBP-3
  • IGF-binding protein 3

General information

  • IGFBP-3 is GH-dependent, due to either a direct Gh effect or regulation by IGF. [1]
  • Like other IGFBPs, IGFBP-3 inhibits IGF action. [1]
  • IGFBP-3 is the predominant IGFBP in adult serum, where it carries approximately 75% of the total IGF, primarily as part of the 150-kd ternary complex. [1]

Classification

Hormone function

  • development and growth
    • apoptosis

    Chemical classification

    • hormone
      • genome-encoded
        • IGFBP family

      Composition

      IGFBP-3

      • The IGFBP-3 gene is located on chromosome 7 in proximity to the gene for IGFBP-1. [1]
      Sequence 
      GASSGGLGP VVRCEPCDA RALAQCAPP 
PAVCAELVR EPGCGCCLT CALSEGQPC 
GIYTERCGS GLRCQPSPD EARPLQALL 
DGRGLCVNA SAVSRLRAY LLPAPPAPG 
NASESEEDR SAGSVESPS VSSTHRVSD 
PKFHPLHSK IIIIKKGHA KDSQRYKVD 
YESQSTDTQ NFSSESKRE TEYGPCRRE 
MEDTLNHLK FLNVLSPRG VHIPNCDKK 
GFYKKKQCR PSKGRKRGF CWCVDKYGQ 
PLPGYTTKG KEDVHCYSM QSK
      UniProt P17936

      Links to other resources

      UniProt P17936
      Ensembl ENSG00000146674
      KEGG hsa:3486

      • Anatomical structure: lipocyte_of_liver

        • IGF-I induced IGFBP-3 and IGFBP-5 proteins in a time-dependent manner without an increase in the corresponding mRNAs. [2]

      • Anatomical structure: hepatocyte

      • Anatomical structure: osteoblast

        Influenced by:

        • AR
          in osteoblast
          • 5-alpha-DHT increased IGFBP-2 and -3 mRNA and protein levels by 6- and 7-fold (for mRNA) and 3- and 5-fold (for protein). [3]

      Targets

      CellRXR-alpha
      brain Present
      heart Present
      hepatocyte Present
      kidney Present
      lung Present
      macrophage Present
      Reference