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Details for messenger / hormone: urocortin 2

EndoNet ID: ENH00198

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Synonyms

  • urocortin 2
  • Ucn2
  • SRP
  • stresscopin-related peptide
  • urocortin-related peptide
  • URP
  • urocortin-2

General information

  • Ucn 2 exerts its effects only in part via corticotropin releasing hormone receptor 2. [1]
  • Ucn2 suppresses host resistance to Listeria monocytogenes infection via up-regulation of interleukin-10 production. [2]
  • Ucn2 has potent cardioprotective effects in the murine heart and its minimal impact on the hypothalamic stress axis. [3]
  • Ucn2 has pro-inflammatory effects in human intestinal cells via the corticotropin-releasing hormone receptor 2 alpha receptor. [4]
  • Suppresses food intake, delays gastric emptying and decreases heat-induced edema. [5]
  • Binds with high affinity to CRF receptors 2-alpha and 2-beta. [5]
  • UCN2 plays a role in circulatory regulation and in heart disease. [6]

Classification

Hormone function

  • homeostasis
    • cardiovascular control

    Chemical classification

    • hormone
      • genome-encoded
        • corticotrophin-releasing factor family

      Composition

      Sequence 
      IVLSLDVPI GLLQILLEQ ARARAAREQ 
ATTNARILA RVGHC
      UniProt Q96RP3

      Links to other resources

      UniProt Q96RP3
      Ensembl ENST00000273610
      KEGG hsa:90226

        Targets

        CellCRF-R2CRF2-beta
        cell of adrenal gland zona fasciculata Present
        cell of adrenal gland zona reticularis Present
        heart Present
        hippocampus Present
        lung Present
        pituitary gland of diencephalon Present
        Influences
        • ↓ ACTH
        placenta Present
        skeleton muscle Present
        stomach Present
        ventromedial nucleus of hypothalamus Present
        Phenotypes
        • hyperactivity of HPA axis
        • hyperphagia
        • hyperdipsia
        Influences
        • ↓ insulin
        Reference