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Details for messenger / hormone: haptoglobin

EndoNet ID: ENH00207

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Synonyms

  • haptoglobin
  • HPT
  • HP

General information

  • Haptoglobin protects against the potentiation of bacterial growth by hemoglobin. [1]
  • Tetramer of 2 alpha chains and 2 beta chains [2]
  • Haptoglobin phenotype is an independent risk factor for cardiovascular disease in individuals with diabetes. [3]
  • Haptoglobin is an unusual secretory protein in that it is proteolytically processed in the endoplasmic reticulum and not in the Golgi. [4]
  • A major function of haptoglobin is to bind hemoglobin (Hb) to form a stable Hp-Hb complex and thereby prevent Hb-induced oxidative tissue damage. [5]

Classification

Hormone function

  • homeostasis
    • cardiovascular control

    Chemical classification

    • hormone
      • genome-encoded

    Composition

    Haptoglobin beta chain (2 times)

    Sequence
    ILGGHLDAK GSFPWQAKM VSHHNLTTG 
    ATLINEQWL LTTAKNLFL NHSENATAK 
    DIAPTLTLY VGKKQLVEI EKVVLHPNY 
    SQVDIGLIK LKQKVSVNE RVMPICLPS 
    KDYAEVGRV GYVSGWGRN ANFKFTDHL 
    KYVMLPVAD QDQCIRHYE GSTVPEKKT 
    PKSPVGVQP ILNEHTFCA GMSKYQEDT 
    CYGDAGSAF AVHDLEEDT WYATGILSF 
    DKSCAVAEY GVYVKVTSI QDWVQKTIA 
    EN
    UniProt P00738

    Haptoglobin alpha chain (2 times)

    Sequence
    VDSGNDVTD IADDGCPKP PEIAHGYVE 
    HSVRYQCKN YYKLRTEGD GVYTLNDKK 
    QWINKAVGD KLPECEADD GCPKPPEIA 
    HGYVEHSVR YQCKNYYKL RTEGDGVYT 
    LNNEKQWIN KAVGDKLPE CEAVCGKPK 
    NPANPVQ
    UniProt P00738

    Links to other resources

    UniProt P00738
    Ensembl ENST00000355906
    KEGG hsa:3240
    • Anatomical structure: adipose_tissue

      Influenced by:

      • PPARgamma1
        in adipose_tissue

    Targets

    Cell
    No records found.
    Reference