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Details for messenger / hormone: TGF-beta 2

EndoNet ID: ENH00213

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Synonyms

  • Cetermin
  • Polyergin
  • BSC-1 cell growth inhibitor
  • glioblastoma-derived T-cell suppressor factor
  • Polyergin
  • BSC-1 cell growth inhibitor
  • glioblastoma-derived T-cell suppressor factor
  • transforming growth factor beta-2
  • TGF-beta 2
  • transforming growth factor beta 2

General information

  • TGF-betas are important growth suppressing factors in normal breast epithelium and their activity is mediated by specific receptors, including TGF-beta-RII. [1]
  • TGF-beta-mediated epithelial-mesenchymal transition of mammary epithelial cells is accompagnied by the loss of laminin-5 production and the upregulation of fibronectin and its alpha-5/beta-1 integrin receptor. [2]
  • TGF-beta2 binds to TbetaRIII, which then recruits TbetaRII and TbetaRI resulting in phosphorylation of TbetaRI and downstream signaling. [3]

Classification

Hormone function

  • development and growth
    • growth stimulation
    • immune response
      • activation

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • TGF-beta family

        Links to other resources

        UniProt P08112
        Ensembl ENST00000366930
        KEGG hsa:7042
        • Anatomical structure: osteoblast

          • In osteoblasts, TGF-beta 2 gene transcription is increased by 1alpha,25(OH)2D3. [4]
          • Osteoblasts expresses mRNA transcripts of TGF-beta1, TGF-beta2, TGF-beta 3, TGF-beta type I and type II receptors. [5]

          Influenced by:

          • VDR
            in osteoblast
        • Anatomical structure: cell_of_endometrium_of_uterus

          • TGF-beta 2 treatment in vitro acts directly on isolated endometrial epithelial cells, independently suppressing promatrilysin protein expression. [6]
          • TGF-beta 2 appears to increase expression of all three mammalian isotypes (TGF-beta 1,2,3). [6]
          • In women, expression of TGF-b1, -b2 and -b3 and the type II receptor occurs in all cell types of the endometrium. [7]
          • Within the stroma, TGF-b2 expression increases during the secretory phase. [7]
          • TGF-b2 is the progesterone- induced, stromal-derived paracrine factor that suppresses epithelial matrilysin production. [7]

          Influenced by:

          • progesterone receptor
            in cell_of_endometrium_of_uterus
            • Northern blot analysis confirmed an increase in TGF-beta 2 mRNA with progesterone treatment. [6]
        • Anatomical structure: fibroblast

        • Anatomical structure: adrenal_gland

          • TGF-β isoform 2 is synthesized by cells in the wall of the dorsal aorta as well as at later stages in both cortical and migrating chromaffin cells within the developing adrenal gland. [8]

        Targets

        CellTGF-beta type II receptorTGFR-3vasorin
        adrenal cortex Present
        aorta Present
        brain Present
        cell of endometrium of uterus Present
        Influences
        • TGF-beta 1
        • LIF
        • interleukin 6
        Present
        dendritic cell in lymphoid tissues follicular Present
        heart Present
        kidney Present
        lung Present
        mammary gland Present
        osteoblast Present
        placenta Present
        Present
        Present
        skeleton muscle Present
        smooth muscle cell Present
        Phenotypes
        • negative regulation of transforming growth factor beta receptor signaling pathway
        Influences
        • TGF-beta 1
        umbilical cord Present
        umbilical vein Present
        umbilical vein endothelial cells Present
        Reference