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Details for messenger / hormone: CRP

EndoNet ID: ENH00217

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Synonyms

  • c-reactive protein
  • CRP
  • c-reactive protein, pentraxin-related

General information

  • C-reactive protein (CRP) is the prototypical acute phase serum protein, rising rapidly in response to inflammation. [1]
  • C-reactive protein-induced upregulation of extracellular matrix metalloproteinase inducer in macrophages. [2]
  • The gene encoding CRP is expressed in adipose tissue. [3]
  • CRP binds to phosphocholine (PC) and related molecules on microorganisms and plays an important role in host defense. [1]
  • CRP is mainly produced by the liver with its synthesis being largely regulated by IL6. [4]
  • Human adipose tissue expresses CRP mRNA, which is negatively correlated with adiponectin expression in the same tissue. [4]
  • Elevated levels of inflammatory markers, particularly C-reactive protein, indicate an increased risk of coronary heart disease. [5]
  • C reactive protein has coherently emerged as an early marker of renal dysfunction. [6]
  • Acute-phase reactants, such as CRP, SAA, sialic acid, fibrinogen and WBC, are associated with arterial stiffness in patients with type 2 diabetes mellitus. [7]
  • Obese subjects have higher circulating levels of C-reactive protein (CRP) than normal subjects, and it has been shown that CRP per se may contribute to atherogenesis. [8]
  • Leptin may directly stimulate the production of CRP independent of fat-cell produced cytokines in older adults. [8]
  • CRP degradation products generated by neutrophil elastase promote neutrophil apoptosis. [9]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    Composition

    unprocessed

    Sequence 
    MEKLLCFLV LTSLSHAFG QTDMSRKAF 
VFPKESDTS YVSLKAPLT KPLKAFTVC 
LHFYTELSS TRGYSIFSY ATKRQDNEI 
LIFWSKDIG YSFTVGGSE ILFEVPEVT 
VAPVHICTS WESASGIVE FWVDGKPRV 
RKSLKKGYT VGAEASIIL GQEQDSFGG 
NFEGSQSLV GDIGNVNMW DFVLSPDEI 
NTIYLGGPF SPNVLNWRA LKYEVQGEV 
FTKPQLWP
    UniProt P02741

    Links to other resources

    UniProt P02741
    Ensembl ENST00000255030
    KEGG hsa:1401

    • Anatomical structure: hepatocyte

      • Great quantities of serum CRP are produced by the liver during the acute phase response. [10]

    • Anatomical structure: adipose_tissue

      • The gene encoding CRP is expressed in adipose tissue. [3]

    Targets

    Cell
    No records found.
    Reference