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Details for messenger / hormone: thrombopoietin

EndoNet ID: ENH00220

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Synonyms

  • megakaryocyte colony-stimulating factor
  • thrombopoietin
  • TPO
  • megakaryocyte colony stimulating factor
  • myeloproliferative leukemia virus oncogene ligand
  • megakaryocyte growth and development factor
  • C-mpl ligand
  • ML
  • MGDF
  • THPO

General information

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    Sequence
    SPAPPACDL RVLSKLLRD SHVLHSRLS 
    QCPEVHPLP TPVLLPAVD FSLGEWKTQ 
    MEETKAQDI LGAVTLLLE GVMAARGQL 
    GPTCLSSLL GQLSGQVRL LLGALQSLL 
    GTQLPPQGR TTAHKDPNA IFLSFQHLL 
    RGKVRFLML VGGSTLCVR RAPPTTAVP 
    SRTSLVLTL NELPNRTSG LLETNFTAS 
    ARTTGSGLL KWQQGFRAK IPGLLNQTS 
    RSLDQIPGY LNRIHELLN GTRGLFPGP 
    SRRTLGAPD ISSGTSDTG SLPPNLQPG 
    YSPSPTHPP TGQYTLFPL PPTLPTPVV 
    QLHPLLPDP SAPTPTPTS PLLNTSYTH 
    SQNLSQEG

    Thrombopoietin isoform 3 mature peptide

    Sequence
    SPAPPACDL RVLSKLLRD SHVLHSRLS 
    QCPEVHPLP TPVLLPAVD FSLGEWKTQ 
    MEETKAQDI LGAVTLLLE GVMAARGQL 
    GPTCLSSLL GQLSGQVRL LLGALQSLL 
    GTQLPPQGR TTAHKDPNA IFLSFQHLL 
    RGKTSGLLE TNFTASART TGSGLLKWQ 
    QGFRAKIPG LLNQTSRSL DQIPGYLNR 
    IHELLNGTR GLFPGPSRR TLGAPDISS 
    GTSDTGSLP PNLQPGYSP SPTHPPTGQ 
    YTLFPLPPT LPTPVVQLH PLLPDPSAP 
    TPTPTSPLL NTSYTHSQN LSQEG

    Thrombopoietin isoform 1 mature peptide

    Sequence
    SPAPPACDL RVLSKLLRD SHVLHSRLS 
    QCPEVHPLP TPVLLPAVD FSLGEWKTQ 
    MEETKAQDI LGAVTLLLE GVMAARGQL 
    GPTCLSSLL GQLSGQVRL LLGALQSLL 
    GTQLPPQGR TTAHKDPNA IFLSFQHLL 
    RGKVRFLML VGGSTLCVR RAPPTTAVP 
    SRTSLVLTL NELPNRTSG LLETNFTAS 
    ARTTGSGLL KWQQGFRAK IPGLLNQTS 
    RSLDQIPGY LNRIHELLN GTRGLFPGP 
    SRRTLGAPD ISSGTSDTG SLPPNLQPG 
    YSPSPTHPP TGQYTLFPL PPTLPTPVV 
    QLHPLLPDP SAPTPTPTS PLLNTSYTH 
    SQNLSQEG

    Thrombopoietin isoform 2 mature peptide

    Sequence
    SPAPPACDL RVLSKLLRD SHVLHSRLS 
    QCPEVHPLP TPVLLPAVD FSLGEWKTQ 
    MEETKAQDI LGAVTLLLE GVMAARGQL 
    GPTCLSSLL GQLSGQVRL LLGALQSLL 
    GTQGRTTAH KDPNAIFLS FQHLLRGKV 
    RFLMLVGGS TLCVRRAPP TTAVPSRTS 
    LVLTLNELP NRTSGLLET NFTASARTT 
    GSGLLKWQQ GFRAKIPGL LNQTSRSLD 
    QIPGYLNRI HELLNGTRG LFPGPSRRT 
    LGAPDISSG TSDTGSLPP NLQPGYSPS 
    PTHPPTGQY TLFPLPPTL PTPVVQLHP 
    LLPDPSAPT PTPTSPLLN TSYTHSQNL 
    SQEG

    Links to other resources

    UniProt P40225
    Ensembl ENST00000445696
    KEGG hsa:7066

      Targets

      CellTPO-R
      No records found.
      Reference