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Details for messenger / hormone: G-CSF

EndoNet ID: ENH00221

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Synonyms

  • lenograstim
  • G-CSF
  • granulocyte colony-stimulating factor
  • pluripoietin
  • filgrastim

General information

  • G-CSF is a 25 kDa secreted glycoprotein encoded by the CSF3 gene and plays a role in the regulation of neutrophil production. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation
      • apoptosis

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • IL-6-type cytokines

        Composition

        long isoform

        Sequence
        ATPLGPASS LPQSFLLKC LEQVRKIQG 
        DGAALQEKL VSECATYKL CHPEELVLL 
        GHSLGIPWA PLSSCPSQA LQLAGCLSQ 
        LHSGLFLYQ GLLQALEGI SPELGPTLD 
        TLQLDVADF ATTIWQQME ELGMAPALQ 
        PTQGAMPAF ASAFQRRAG GVLVASHLQ 
        SFLEVSYRV LRHLAQP
        UniProt P09919-1

        Links to other resources

        UniProt P09919
        Ensembl ENST00000225474
        KEGG hsa:1440
        • Anatomical structure: monocyte

        • Anatomical structure: fibroblast

        • Anatomical structure: propria_mucosa_of_bronchus

        Targets

        CellG-CSF-R
        neutrophil granulocyte Present
        Phenotypes
        • regulation of neutrophil production
        Reference